Phase II trial of esorubicin (4′ deoxydoxorubicin) in cancers of the breast, colon, kidney, lung and melanoma

Theodore A. Braich; Sydney E. Salmon; Aurelia Robertone; David S. Alberts; Stephen E. Jones; Thomas P. Miller; Harinder S. Garewal

doi:10.1007/BF00179595

Phase II trial of esorubicin (4′ deoxydoxorubicin) in cancers of the breast, colon, kidney, lung and melanoma

Theodore A. Braich, Sydney E. Salmon, Aurelia Robertone, David S. Alberts, Stephen E. Jones, Thomas P. Miller, Harinder S. Garewal

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7 Scopus citations

Abstract

A phase II trial of esorubicin (4′ deoxydoxorubicin) was performed in patients with cancers of the breast, colon, kidney, lung and melanoma. Two partial responses were observed out of 16 patients with breast cancer treated with esorubicin. No objective responses (complete or partial) were seen in patients with colon cancer (18 patients), lung cancer (12 patients), renal cell cancer (12 patients) and melanoma (18 patients). Myelosuppression was the most significant toxicity encountered with granulocytopenia (neutrophils < 1,000) observed in 38% of patients. As discussed, we feel that further investigation of esorubicin in anthracyclinesensitive tumors is warranted.

Original language	English (US)
Pages (from-to)	269-274
Number of pages	6
Journal	Investigational New Drugs
Volume	4
Issue number	3
DOIs	https://doi.org/10.1007/BF00179595
State	Published - Sep 1986

Keywords

esorubicin
phase II

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)

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10.1007/BF00179595

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title = "Phase II trial of esorubicin (4′ deoxydoxorubicin) in cancers of the breast, colon, kidney, lung and melanoma",

abstract = "A phase II trial of esorubicin (4′ deoxydoxorubicin) was performed in patients with cancers of the breast, colon, kidney, lung and melanoma. Two partial responses were observed out of 16 patients with breast cancer treated with esorubicin. No objective responses (complete or partial) were seen in patients with colon cancer (18 patients), lung cancer (12 patients), renal cell cancer (12 patients) and melanoma (18 patients). Myelosuppression was the most significant toxicity encountered with granulocytopenia (neutrophils < 1,000) observed in 38% of patients. As discussed, we feel that further investigation of esorubicin in anthracyclinesensitive tumors is warranted.",

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AU - Braich, Theodore A.

AU - Salmon, Sydney E.

AU - Robertone, Aurelia

AU - Alberts, David S.

AU - Jones, Stephen E.

AU - Miller, Thomas P.

AU - Garewal, Harinder S.

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AB - A phase II trial of esorubicin (4′ deoxydoxorubicin) was performed in patients with cancers of the breast, colon, kidney, lung and melanoma. Two partial responses were observed out of 16 patients with breast cancer treated with esorubicin. No objective responses (complete or partial) were seen in patients with colon cancer (18 patients), lung cancer (12 patients), renal cell cancer (12 patients) and melanoma (18 patients). Myelosuppression was the most significant toxicity encountered with granulocytopenia (neutrophils < 1,000) observed in 38% of patients. As discussed, we feel that further investigation of esorubicin in anthracyclinesensitive tumors is warranted.

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Phase II trial of esorubicin (4′ deoxydoxorubicin) in cancers of the breast, colon, kidney, lung and melanoma

Abstract

Keywords

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