Pharmacological regulation of blood glucose levels in non-insulin- dependent diabetes mellitus

Rubin Bressler, David G. Johnson

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations


Non-insulin-dependent diabetes mellitus is a metabolic disease that is common and is characterized by insulin insufficiency and resistance. Measures such as body weight reduction and exercise improve the metabolic defects, but pharmacological therapy is the most frequently used and successful therapy. The sulphonylureas stimulate insulin secretion. Metformin and troglitazone increase disposal and decrease hepatic glucose output without causing hypoglycemia. Acarbose is a dietary aid that spreads the dietary carbohydrate challenge to endogenous insulin over time. These pharmacological agents, either alone or in combination, can improve blood glucose regulation in patients with non-insulin-dependent diabetes mellitus.

Original languageEnglish (US)
Pages (from-to)836-848
Number of pages13
JournalArchives of internal medicine
Issue number8
StatePublished - Apr 28 1997

ASJC Scopus subject areas

  • Internal Medicine


Dive into the research topics of 'Pharmacological regulation of blood glucose levels in non-insulin- dependent diabetes mellitus'. Together they form a unique fingerprint.

Cite this