Abstract
Mitochondrial dysfunction is a key pathophysiological mediator in a variety of disease states, including cardiovascular disease, metabolic syndrome, neurodegeneration, and acute organ injury. Pharmacological activation of mitochondrial biogenesis enhances mitochondrial content and oxidative metabolism and improves organ function in conditions involving mitochondrial dysfunction. Due to the complexity of signaling cascades and transcriptional complexes that promote the assembly and function of mitochondria, identification of specific activators of mitochondrial biogenesis is limited. This chapter provides rationale for mitochondrial biogenesis as a therapeutic strategy, discusses the role of mitochondrial dysfunction in acute and chronic disease, and outlines the current state of pharmacological activators of mitochondrial biogenesis and their effects on disease outcomes.
Original language | English (US) |
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Title of host publication | Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants |
Publisher | Wiley |
Pages | 569-592 |
Number of pages | 24 |
Volume | 2-2 |
ISBN (Electronic) | 9781119329725 |
ISBN (Print) | 9781119329701 |
DOIs | |
State | Published - Feb 21 2018 |
Keywords
- Disease outcomes
- Mitochondrial homeostasis
- Oxidative metabolism
- Therapeutics
ASJC Scopus subject areas
- General Chemistry
- Pharmacology, Toxicology and Pharmaceutics(all)
- General Biochemistry, Genetics and Molecular Biology