Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs

Julia H. Indik; Raymond L. Woosley

doi:10.1016/j.ccep.2010.06.001

Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs

Julia H. Indik
, Raymond L. Woosley

Medicine

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

This article describes the pharmacology of antiarrhythmic medications. Although these medications are broadly considered in terms of their blockade of either sodium or potassium channels, they act by a variety of pharmacodynamic mechanisms. Elimination may be via hepatic metabolism or renal mechanisms, or a combination. In particular, interactions between antiarrhythmic medications and other drugs that interfere with hepatic metabolism by P450 enzymes is a source for toxicity.

Original language	English (US)
Pages (from-to)	341-358
Number of pages	18
Journal	Cardiac Electrophysiology Clinics
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.ccep.2010.06.001
State	Published - Sep 2010

Keywords

Antiarrhythmic medications
Drug interactions
Pharmacodynamics
Pharmacokinetics

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1016/j.ccep.2010.06.001

Cite this

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title = "Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs",

abstract = "This article describes the pharmacology of antiarrhythmic medications. Although these medications are broadly considered in terms of their blockade of either sodium or potassium channels, they act by a variety of pharmacodynamic mechanisms. Elimination may be via hepatic metabolism or renal mechanisms, or a combination. In particular, interactions between antiarrhythmic medications and other drugs that interfere with hepatic metabolism by P450 enzymes is a source for toxicity.",

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year = "2010",

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AU - Indik, Julia H.

AU - Woosley, Raymond L.

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AB - This article describes the pharmacology of antiarrhythmic medications. Although these medications are broadly considered in terms of their blockade of either sodium or potassium channels, they act by a variety of pharmacodynamic mechanisms. Elimination may be via hepatic metabolism or renal mechanisms, or a combination. In particular, interactions between antiarrhythmic medications and other drugs that interfere with hepatic metabolism by P450 enzymes is a source for toxicity.

KW - Antiarrhythmic medications

KW - Drug interactions

KW - Pharmacodynamics

KW - Pharmacokinetics

UR - https://www.scopus.com/pages/publications/78149379696

UR - https://www.scopus.com/pages/publications/78149379696#tab=citedBy

U2 - 10.1016/j.ccep.2010.06.001

DO - 10.1016/j.ccep.2010.06.001

M3 - Review article

AN - SCOPUS:78149379696

SN - 1877-9182

VL - 2

SP - 341

EP - 358

JO - Cardiac Electrophysiology Clinics

JF - Cardiac Electrophysiology Clinics

IS - 3

ER -

Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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