Pharmacokinetics/Pharmacodynamics of Antiarrhythmic Drugs

Julia H. Indik, Raymond L. Woosley

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


This article describes the pharmacology of antiarrhythmic medications. Although these medications are broadly considered in terms of their blockade of either sodium or potassium channels, they act by a variety of pharmacodynamic mechanisms. Elimination may be via hepatic metabolism or renal mechanisms, or a combination. In particular, interactions between antiarrhythmic medications and other drugs that interfere with hepatic metabolism by P450 enzymes is a source for toxicity.

Original languageEnglish (US)
Pages (from-to)341-358
Number of pages18
JournalCardiac Electrophysiology Clinics
Issue number3
StatePublished - Sep 2010


  • Antiarrhythmic medications
  • Drug interactions
  • Pharmacodynamics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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