Abstract
Purpose: To determine the anatomic characteristics and pharmacokinetic properties of intravitreally-placed aflibercept in a rabbit model. Materials and methods: Four Dutch-belted rabbits underwent intravitreal injection with I-124-aflibercept. Serial imaging with PET/CT imaging was performed on days 0, 2, 5, 7, 14, 21, 28 and 35. Measured radioactivity emission in becquerels/mL was used to calculate the half-lives for aflibercept. Results: I-124 aflibercept was confined within the vitreous cavity for the duration of the study. I-124 aflibercept could be detected in the vitreous cavity until day 28 and the average retention time with standard error after correction for radioactive decay was 4.58±0.07 days. Conclusions: I-124 aflibercept was only visible in the vitreous cavity by PET/CT imaging following intravitreal injection. The retention properties were found to be comparable to those measured by other reported methods.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1171-1174 |
| Number of pages | 4 |
| Journal | Current Eye Research |
| Volume | 37 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2012 |
Keywords
- Aflibercept
- Iodine-124
- Pharmacokinetics
- Positron emission tomography
- Radiolabeling
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
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