TY - JOUR
T1 - PET/CT of dementia
AU - Zukotynski, Katherine
AU - Kuo, Phillip H.
AU - Mikulis, David
AU - Rosa-Neto, Pedro
AU - Strafella, Antonio P.
AU - Subramaniam, Rathan M.
AU - Black, Sandra E.
N1 - Publisher Copyright:
© American Roentgen Ray Society.
PY - 2018/8
Y1 - 2018/8
N2 - OBJECTIVE. In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field. CONCLUSION. Standard-of-care imaging for dementia includes CT and MRI, primarily for excluding vascular lesions or masses, detecting atrophy, and monitoring disease severity. PET/CT is a powerful functional modality that can differentiate dementia types and influence management. Fluorine-18-FDG PET/CT reveals the spatial pattern of glucose metabolism in the brain. More recently, radiotracers for PET have been developed that bind to amyloid protein, tau protein, and neuroinflammatory markers.
AB - OBJECTIVE. In this article, we review the literature on PET/CT in the management of dementia, present evidence for best clinical practices, and discuss recent advances in the field. CONCLUSION. Standard-of-care imaging for dementia includes CT and MRI, primarily for excluding vascular lesions or masses, detecting atrophy, and monitoring disease severity. PET/CT is a powerful functional modality that can differentiate dementia types and influence management. Fluorine-18-FDG PET/CT reveals the spatial pattern of glucose metabolism in the brain. More recently, radiotracers for PET have been developed that bind to amyloid protein, tau protein, and neuroinflammatory markers.
KW - Amyloid
KW - Dementia
KW - Imaging
KW - PET/CT
KW - Tau
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U2 - 10.2214/AJR.18.19822
DO - 10.2214/AJR.18.19822
M3 - Article
C2 - 29949415
AN - SCOPUS:85052405694
SN - 0361-803X
VL - 211
SP - 246
EP - 259
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 2
ER -