Perspectives on whole-organ assembly: Moving toward transplantation on demand

Alejandro Soto-Gutierrez, Jason A. Wertheim, Harald C. Ott, Thomas W. Gilbert

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


There is an ever-growing demand for transplantable organs to replace acute and chronically damaged tissues. This demand cannot be met by the currently available donor organs. Efforts to provide an alternative source have led to the development of organ engineering, a discipline that combines cell biology, tissue engineering, and cell/organ transplantation. Over the last several years, engineered organs have been implanted into rodent recipients and have shown modest function. In this article, we summarize the most recent advances in this field and provide a perspective on the challenges of translating this promising new technology into a proven regenerative therapy.

Original languageEnglish (US)
Pages (from-to)3817-3823
Number of pages7
JournalJournal of Clinical Investigation
Issue number11
StatePublished - Nov 1 2012
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Perspectives on whole-organ assembly: Moving toward transplantation on demand'. Together they form a unique fingerprint.

Cite this