TY - JOUR
T1 - Persistent organic pollutants and children's respiratory health
T2 - The role of cytokines and inflammatory biomarkers
AU - Gascon, Mireia
AU - Sunyer, Jordi
AU - Martínez, David
AU - Guerra, Stefano
AU - Lavi, Iris
AU - Torrent, Maties
AU - Vrijheid, Martine
N1 - Funding Information:
This study was supported by grants from the Spanish Ministry of Health ( FIS PS09/00362 ) and the RecerCaixa ( 2010ACUP 00349 ). The Menorca cohort also received funding from the Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0041), the Spanish Ministry of Health (FIS 97/0588, 00/0021-2, PI061756 and PS0901958), Beca de la IV convocatoria de Ayudas a la Investigación en Enfermedades Neurodegenerativas de “La Caixa”, and EC Contract No. QLK4-CT-2000-00263. Finally the authors would like to be grateful to the families and schools in Menorca for participating in the study.
PY - 2014/8
Y1 - 2014/8
N2 - Evidence of adverse effects of persistent organic pollutants (POPs) on the developmental respiratory and immune systems in children is still limited, and the biological mechanisms behind such effects are not fully understood. The aim of the present study is to evaluate the effects of prenatal DDE, HCB and σPCB exposure on children's respiratory health from birth to 14. years and to evaluate the role of immune biomarkers in these associations.We measured prenatal DDE, HCB and σPCB levels in 405 participants of the INMA-Menorca birth cohort (Spain) and collected information on wheeze, chest infections, atopy and asthma from birth until the age of 14. years. At age 4. years, 275 children provided serum samples and IL6, IL8, IL10, TNFα and C-reactive protein were measured. We applied linear and logistic regression models and generalized estimating equations.Prenatal DDE was associated with wheeze at age 4. years [RR (95% CI) per doubling of concentration=1.35 (1.07, 1.71)], but not thereafter. Prenatal HCB was associated with wheeze [1.58 (1.04, 2.41)] and chest infections [1.89 (1.10, 3.25)] at age 10. years. No associations were found with σPCBs. IL10 levels increased with increasing POP concentration, with HCB showing the strongest association [β (95% CI)=0.22 (0.02, 0.41)]. IL8, IL10 and TNFα were associated with wheeze and/or chest infections and IL10 was associated with asthma.Prenatal DDE and HCB exposure was associated with respiratory health of children at different ages. This study further suggests a possible role of IL10, but not of the other immune biomarkers examined, as an early marker of chronic immune-related health effects of POPs.
AB - Evidence of adverse effects of persistent organic pollutants (POPs) on the developmental respiratory and immune systems in children is still limited, and the biological mechanisms behind such effects are not fully understood. The aim of the present study is to evaluate the effects of prenatal DDE, HCB and σPCB exposure on children's respiratory health from birth to 14. years and to evaluate the role of immune biomarkers in these associations.We measured prenatal DDE, HCB and σPCB levels in 405 participants of the INMA-Menorca birth cohort (Spain) and collected information on wheeze, chest infections, atopy and asthma from birth until the age of 14. years. At age 4. years, 275 children provided serum samples and IL6, IL8, IL10, TNFα and C-reactive protein were measured. We applied linear and logistic regression models and generalized estimating equations.Prenatal DDE was associated with wheeze at age 4. years [RR (95% CI) per doubling of concentration=1.35 (1.07, 1.71)], but not thereafter. Prenatal HCB was associated with wheeze [1.58 (1.04, 2.41)] and chest infections [1.89 (1.10, 3.25)] at age 10. years. No associations were found with σPCBs. IL10 levels increased with increasing POP concentration, with HCB showing the strongest association [β (95% CI)=0.22 (0.02, 0.41)]. IL8, IL10 and TNFα were associated with wheeze and/or chest infections and IL10 was associated with asthma.Prenatal DDE and HCB exposure was associated with respiratory health of children at different ages. This study further suggests a possible role of IL10, but not of the other immune biomarkers examined, as an early marker of chronic immune-related health effects of POPs.
KW - Asthma
KW - Chest infections
KW - Children
KW - Cytokines
KW - Persistent organic pollutants (POPs)
KW - Wheeze
UR - http://www.scopus.com/inward/record.url?scp=84900812505&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900812505&partnerID=8YFLogxK
U2 - 10.1016/j.envint.2014.04.021
DO - 10.1016/j.envint.2014.04.021
M3 - Article
C2 - 24837163
AN - SCOPUS:84900812505
SN - 0160-4120
VL - 69
SP - 133
EP - 140
JO - Environment international
JF - Environment international
ER -