Persistent and specific influences of early acoustic environments on primary auditory cortex

Li I. Zhang, Shaowen Bao, Michael M. Merzenich

Research output: Contribution to journalArticlepeer-review

331 Scopus citations

Abstract

This study demonstrates that the adult form of 'tonotopic maps' of sound frequency in the rat primary auditory cortex (A1) arises from parallel developmental processes involving two cortical zones: the progressive differentiation and refinement of selectively tone-responsive receptive fields within an initially broadly-tuned posterior zone, and the progressive loss of tone-evoked, short-latency response over an initially large, very broadly tuned anterior zone. The formation of tonotopic maps in A1 was specifically influenced by a rat pup's early acoustic environments. Exposure to pulsed tones resulted in accelerated emergence and an expansion of A1 representations of those specific tone frequencies, as well as a deteriorated tonotopicity and broader-than-normal receptive fields. Thus, auditory experiences during early postnatal development are important in shaping the functional development of auditory cortical representations of specific acoustic environments.

Original languageEnglish (US)
Pages (from-to)1123-1130
Number of pages8
JournalNature neuroscience
Volume4
Issue number11
DOIs
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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