Peripheral Delivery of a ROCK Inhibitor Improves Learning and Working Memory

Matthew J. Huentelman, Dietrich A. Stephan, Joshua Talboom, Jason J. Corneveaux, David M. Reiman, Jill D. Gerber, Carol A. Barnes, Gene E. Alexander, Eric M. Reiman, Heather A. Bimonte-Nelson

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Previously, utilizing a series of genome-wide association, brain imaging, and gene expression studies we implicated the KIBRA gene and the RhoA/ROCK pathway in hippocampal-mediated human memory. Here we show that peripheral administration of the ROCK inhibitor hydroxyfasudil improves spatial learning and working memory in the rodent model. This study supports the action of ROCK on learning and memory, suggests the potential value of ROCK inhibition for the promotion of cognition in humans, and highlights the powerful potential of unbiased genome-wide association studies to inform potential novel uses for existing pharmaceuticals.

Original languageEnglish (US)
Pages (from-to)218-223
Number of pages6
JournalBehavioral Neuroscience
Issue number1
StatePublished - Feb 2009


  • ROCK
  • aging
  • fasudil
  • learning
  • memory

ASJC Scopus subject areas

  • Behavioral Neuroscience


Dive into the research topics of 'Peripheral Delivery of a ROCK Inhibitor Improves Learning and Working Memory'. Together they form a unique fingerprint.

Cite this