Periaortic ventricular tachycardia in structural heart disease: Evidence of localized reentrant mechanisms

Takuro Nishimura, Andrew D. Beaser, Zaid A. Aziz, Gaurav A. Upadhyay, Cevher Ozcan, Michael Raiman, Dalise Y. Shatz, Stephanie A. Besser, Nathan A. Shatz, Hemal M. Nayak, Roderick Tung

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: The mechanisms for scar-related ventricular tachycardia (VT) originating from the periaortic region remain incompletely characterized. Objective: The purpose of this study was to map the circuits responsible for periaortic VT in high resolution. Methods: Cases with periaortic VT (2016–2020) were analyzed to characterize the substrate and mechanisms with multielectrode mapping. Periaortic VT was defined as low-voltage and/or deceleration zones within 2 cm of the left ventriculoaortic junction with a corresponding critical site during VT. Results: Forty-nine periaortic monomorphic VTs were analyzed in 30 patients (25% of all patients with nonischemic cardiomyopathy). Isolated periaortic substrate was observed in 27% of patients, with 73% having concomitant scar, most commonly in the mid-septum (47%). Deceleration zones were equally prevalent on the septal and lateral portions of the periaortic region (87% vs 73%; P = .19). During activation mapping of VT (tachycardia cycle length 392 ± 105 ms), localized reentrant patterns of activation (14 mm [10–17 mm] × 10 mm [7–14 mm]) were demonstrated in 63% and 37% of VTs showed centrifugal activation, consistent with a focal breakout pattern. Ninety-three percent of VTs fulfilled criteria for a reentrant mechanism. Sixty-five percent of reentrant circuits had endocardial activation gaps within the tachycardia cycle length (3-dimensional circuitry), which were associated with higher rates of recurrence as compared with 2-dimensional complete circuits at 1 year (73% vs 37%; P = .028). Conclusion: Periaortic VTs were observed in 25% of patients with nonischemic cardiomyopathy and scar-related VT. For the first time, localized reentry confined to this anatomically challenging region was demonstrated as the predominant mechanism by high-resolution circuit activation mapping.

Original languageEnglish (US)
Pages (from-to)1271-1279
Number of pages9
JournalHeart Rhythm
Volume17
Issue number8
DOIs
StatePublished - Aug 2020
Externally publishedYes

Keywords

  • Catheter ablation
  • High-resolution mapping
  • Periaortic VT
  • Reentry

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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