TY - GEN
T1 - Performance of an Ideal Attenuation and Scatter Correction Strategy for a Next-Generation SPECT System Dedicated to Quantitative Clinical Brain Imaging
AU - Auer, Benjamin
AU - De Beenhouwer, Jan
AU - Zeraatkar, Navid
AU - Kuo, Philip H.
AU - Furenlid, Lars R.
AU - King, Michael A.
N1 - Funding Information:
Manuscript received December 12, 2019. Research reported in this publication was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Numbers R01 EB022521. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2019 IEEE.
PY - 2019/10
Y1 - 2019/10
N2 - A next-generation, adaptive, multi-pinhole system, AdaptiSPECT-C, dedicated to SPECT brain imaging is currently under development in our research team. Attenuation and scatter correction have proven to be critical to enhance image quality and quantification for brain imaging. The motivation for this investigation was to determine the enhancement in image quality by adding scatter correction strategy in addition to attenuation correction for brain imaging with AdaptiSPECT-C. An ideal scatter correction strategy was investigated in this GATE simulation study using a brain perfusion phantom and compared to the reference case for which an air attenuation medium was considered. We demonstrated that the use of the attenuation and the ideal scatter correction strategy significantly enhanced the imaging performance of AdaptiSPECT-C in case of clinical 123I brain perfusion imaging. In addition, our study concluded that the use of an attenuation correction without compensating for scatter strongly degrades the contrast of the reconstruction, despite a quantitative improvement compared to the case for which no correction was used.
AB - A next-generation, adaptive, multi-pinhole system, AdaptiSPECT-C, dedicated to SPECT brain imaging is currently under development in our research team. Attenuation and scatter correction have proven to be critical to enhance image quality and quantification for brain imaging. The motivation for this investigation was to determine the enhancement in image quality by adding scatter correction strategy in addition to attenuation correction for brain imaging with AdaptiSPECT-C. An ideal scatter correction strategy was investigated in this GATE simulation study using a brain perfusion phantom and compared to the reference case for which an air attenuation medium was considered. We demonstrated that the use of the attenuation and the ideal scatter correction strategy significantly enhanced the imaging performance of AdaptiSPECT-C in case of clinical 123I brain perfusion imaging. In addition, our study concluded that the use of an attenuation correction without compensating for scatter strongly degrades the contrast of the reconstruction, despite a quantitative improvement compared to the case for which no correction was used.
KW - I SPECT imaging
KW - next-generation clinical system
KW - scatter and attenuation correction
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U2 - 10.1109/NSS/MIC42101.2019.9059942
DO - 10.1109/NSS/MIC42101.2019.9059942
M3 - Conference contribution
AN - SCOPUS:85083581483
T3 - 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
BT - 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
Y2 - 26 October 2019 through 2 November 2019
ER -