TY - JOUR
T1 - Perchlorate trophic transfer increases tissue concentrations above ambient water exposure alone in a predatory fish
AU - Furin, Christoff G.
AU - Von Hippel, Frank A.
AU - Hagedorn, Birgit
AU - O'Hara, Todd M.
N1 - Funding Information:
Lauren Smayda assisted with feeding experiments, Richard Bernhardt assisted with fish collection, and Benjamin Applegate helped with the analytical chemistry. Research reported in this publication was supported by the National Institute of General Medical Sciences of the National Institutes of Health under award P20GM103395. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Funding was also provided by NIH grant 1RO1ES017039-01A1. Fish were collected under Alaska Department of Fish and Game permits SF-2007-060 and SF-2007-019, and all research protocols were approved by the UAA Institutional Animal Care and Use Committee; IACUC # 2007vonhi1.
PY - 2013/9/17
Y1 - 2013/9/17
N2 - This study examined effects of varying concentrations of the environmental contaminant perchlorate in northern pike (Esox lucius) based on exposure in water and/or from prey (threespine stickleback, Gasterosteus aculeatus). Routes of exposure to pike were through contaminated water at 0, 10, or 100 mg/L perchlorate for 49 d and/or through feeding, 1 per day over 14 d, sticklebacks that were previously maintained in water at 0, 10, or 100 mg/L perchlorate. Both water and food significantly contributed to pike tissue concentrations of perchlorate as compared to controls, but, as expected for a water-soluble contaminant, perchlorate did not biomagnify from prey to predatory fish. Pike gastrointestinal tissue retained significantly more perchlorate than other tissues combined. Route of exposure and concentration of perchlorate in various media are important to consider in risk assessment when evaluating uptake and tissue concentration of perchlorate because significantly higher tissue concentrations may result from combined prey and water exposures than from prey or water exposures alone in a concentration-dependent manner.
AB - This study examined effects of varying concentrations of the environmental contaminant perchlorate in northern pike (Esox lucius) based on exposure in water and/or from prey (threespine stickleback, Gasterosteus aculeatus). Routes of exposure to pike were through contaminated water at 0, 10, or 100 mg/L perchlorate for 49 d and/or through feeding, 1 per day over 14 d, sticklebacks that were previously maintained in water at 0, 10, or 100 mg/L perchlorate. Both water and food significantly contributed to pike tissue concentrations of perchlorate as compared to controls, but, as expected for a water-soluble contaminant, perchlorate did not biomagnify from prey to predatory fish. Pike gastrointestinal tissue retained significantly more perchlorate than other tissues combined. Route of exposure and concentration of perchlorate in various media are important to consider in risk assessment when evaluating uptake and tissue concentration of perchlorate because significantly higher tissue concentrations may result from combined prey and water exposures than from prey or water exposures alone in a concentration-dependent manner.
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U2 - 10.1080/15287394.2013.836693
DO - 10.1080/15287394.2013.836693
M3 - Article
C2 - 24188192
AN - SCOPUS:84887843568
SN - 1528-7394
VL - 76
SP - 1072
EP - 1084
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 18
ER -