TY - JOUR
T1 - Perceived functioning has ethnic-specific associations in systemic sclerosis
T2 - Another dimension of personalized medicine
AU - McNearney, Terry A.
AU - Hunnicutt, Sonya E.
AU - Fischbach, Michael
AU - Friedman, Alan W.
AU - Aguilar, Martha
AU - Ahn, Chul W.
AU - Reveille, John D.
AU - Lisse, Jeffrey R.
AU - Baethge, Bruce A.
AU - Goel, Niti
AU - Mayes, Maureen D.
PY - 2009/12
Y1 - 2009/12
N2 - Objective. To measure self-reported physical and mental functioning and associated clinical features at study entry in 3 ethnic groups with systemic sclerosis (SSc). Methods. Sixty Hispanic, 39 African American, and 104 Caucasian patients with recent-onset SSc (< 5 yrs) were assessed for perceived physical and mental functioning, using the Medical Outcomes Study Short Form-36 (SF-36) and Scleroderma-Health Assessment Questionnaire (Scleroderma-HAQ). Socioeconomic, demographic, clinical, immunologic, immunogenetic, behavioral, and psychological variables (Interpersonal Support Evaluation List, ISEL; Illness Behavior Questionnaire, IBQ; andArthritis Helplessness Index,AHI) were analyzed by linear regression models for associations with SF-36 and mHAQ scores as dependent variables. Results. Perceived physical functioning scores had ethnic-specific associations with AHI > fatigue scores > IBQ > clinical variables (hypertension, skin score, and percentage predicted DLCO). Scleroderma-HAQ scores had ethnic-specific associations with IBQ > AHI scores > most clinical and laboratory variables. Decreased mental component summary (MCS) scores associated with AHI > ISEL. Ethnic-specific immunogenetic variables HLA-DQB1*0202 (Caucasian) and HLA-DRB1*11 (African American), and HLA-DQA1*0501 (Hispanic) also associated with MCS. Antinuclear autoantibodies, anti-topoisomerase I, and RNA polymerases I and III also demonstrated associations with functioning in African American and Hispanic groups. Conclusion. Clinical, psychosocial, and immunogenetic variables had ethnic-specific associations with perceived physical and mental functioning. Consideration of ethnic-specific psychological and behavioral support in designing more personalized, relevant therapeutic interventions for the patient may improve therapeutic efficacy in SSc. The Journal of Rheumatology
AB - Objective. To measure self-reported physical and mental functioning and associated clinical features at study entry in 3 ethnic groups with systemic sclerosis (SSc). Methods. Sixty Hispanic, 39 African American, and 104 Caucasian patients with recent-onset SSc (< 5 yrs) were assessed for perceived physical and mental functioning, using the Medical Outcomes Study Short Form-36 (SF-36) and Scleroderma-Health Assessment Questionnaire (Scleroderma-HAQ). Socioeconomic, demographic, clinical, immunologic, immunogenetic, behavioral, and psychological variables (Interpersonal Support Evaluation List, ISEL; Illness Behavior Questionnaire, IBQ; andArthritis Helplessness Index,AHI) were analyzed by linear regression models for associations with SF-36 and mHAQ scores as dependent variables. Results. Perceived physical functioning scores had ethnic-specific associations with AHI > fatigue scores > IBQ > clinical variables (hypertension, skin score, and percentage predicted DLCO). Scleroderma-HAQ scores had ethnic-specific associations with IBQ > AHI scores > most clinical and laboratory variables. Decreased mental component summary (MCS) scores associated with AHI > ISEL. Ethnic-specific immunogenetic variables HLA-DQB1*0202 (Caucasian) and HLA-DRB1*11 (African American), and HLA-DQA1*0501 (Hispanic) also associated with MCS. Antinuclear autoantibodies, anti-topoisomerase I, and RNA polymerases I and III also demonstrated associations with functioning in African American and Hispanic groups. Conclusion. Clinical, psychosocial, and immunogenetic variables had ethnic-specific associations with perceived physical and mental functioning. Consideration of ethnic-specific psychological and behavioral support in designing more personalized, relevant therapeutic interventions for the patient may improve therapeutic efficacy in SSc. The Journal of Rheumatology
KW - Hispanic
KW - Illness behavior questionnaire
KW - Interpersonal support evaluation list
KW - Medical outcomes study short form-36
KW - Personalized medicine
KW - Scleroderma health assessment questionnaire
UR - https://www.scopus.com/pages/publications/72449128201
UR - https://www.scopus.com/pages/publications/72449128201#tab=citedBy
U2 - 10.3899/jrheum.090295
DO - 10.3899/jrheum.090295
M3 - Article
C2 - 19918038
AN - SCOPUS:72449128201
SN - 0315-162X
VL - 36
SP - 2724
EP - 2732
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 12
ER -