Per-and polyfluoroalkyl substance and cardio metabolic markers in firefighters

Naila Khalil, Alan M. Ducatman, Shripad Sinari, Dean Billheimer, Chengcheng Hu, Sally Littau, Jefferey L. Burgess

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: To evaluate if serum polyfluoroalkyl substances (PFAS) wereassociated with cardiometabolic markers. Methods: Serum PFAS wereevaluated in 38 Arizona firefighters and 49 participants from the 2009 to2010 National Health and Nutrition Examination Survey (NHANES). Cardiometabolic markers including carotid intima-medial thickness (CIMT) were measured in the firefighters. Results: Firefighters had elevated perfluorohexanesulfonic acid (PFHxS) and lower perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) compared to NHANESparticipants; for nine of the other 12 PFAS the values were not significantlydifferent. There were significant negative associations among firefightersbetween perfluorodecanoic acid (PFDeA) and total cholesterol and PFUAand interleukin-6. PFAS concentrations were not associated with CIMT. Conclusion: PFHxS levels were elevated in firefighters compared toNHANES subjects. Serum PFAS concentrations were not associated with increased cardiometabolic risk measures in this population of firefighters.

Original languageEnglish (US)
Pages (from-to)1076-1081
Number of pages6
JournalJournal of occupational and environmental medicine
Volume62
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • National Health and Nutrition Examination Survey (NHANES)
  • cardiometabolic
  • cardiovascular
  • carotid intima-media thickness (CIMT)
  • firefighters
  • markers
  • per-and polyfluoroalkyl substances (PFAS)

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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