Per-and polyfluoroalkyl substance and cardio metabolic markers in firefighters

Naila Khalil; Alan M. Ducatman; Shripad Sinari; Dean Billheimer; Chengcheng Hu; Sally Littau; Jefferey L. Burgess

doi:10.1097/JOM.0000000000002062

Per-and polyfluoroalkyl substance and cardio metabolic markers in firefighters

Naila Khalil, Alan M. Ducatman, Shripad Sinari, Dean Billheimer, Chengcheng Hu, Sally Littau, Jefferey L. Burgess

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Objective: To evaluate if serum polyfluoroalkyl substances (PFAS) wereassociated with cardiometabolic markers. Methods: Serum PFAS wereevaluated in 38 Arizona firefighters and 49 participants from the 2009 to2010 National Health and Nutrition Examination Survey (NHANES). Cardiometabolic markers including carotid intima-medial thickness (CIMT) were measured in the firefighters. Results: Firefighters had elevated perfluorohexanesulfonic acid (PFHxS) and lower perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) compared to NHANESparticipants; for nine of the other 12 PFAS the values were not significantlydifferent. There were significant negative associations among firefightersbetween perfluorodecanoic acid (PFDeA) and total cholesterol and PFUAand interleukin-6. PFAS concentrations were not associated with CIMT. Conclusion: PFHxS levels were elevated in firefighters compared toNHANES subjects. Serum PFAS concentrations were not associated with increased cardiometabolic risk measures in this population of firefighters.

Original language	English (US)
Pages (from-to)	1076-1081
Number of pages	6
Journal	Journal of occupational and environmental medicine
Volume	62
Issue number	12
DOIs	https://doi.org/10.1097/JOM.0000000000002062
State	Published - Dec 2020

Keywords

National Health and Nutrition Examination Survey (NHANES)
cardiometabolic
cardiovascular
carotid intima-media thickness (CIMT)
firefighters
markers
per-and polyfluoroalkyl substances (PFAS)

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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10.1097/JOM.0000000000002062

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title = "Per-and polyfluoroalkyl substance and cardio metabolic markers in firefighters",

abstract = "Objective: To evaluate if serum polyfluoroalkyl substances (PFAS) wereassociated with cardiometabolic markers. Methods: Serum PFAS wereevaluated in 38 Arizona firefighters and 49 participants from the 2009 to2010 National Health and Nutrition Examination Survey (NHANES). Cardiometabolic markers including carotid intima-medial thickness (CIMT) were measured in the firefighters. Results: Firefighters had elevated perfluorohexanesulfonic acid (PFHxS) and lower perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) compared to NHANESparticipants; for nine of the other 12 PFAS the values were not significantlydifferent. There were significant negative associations among firefightersbetween perfluorodecanoic acid (PFDeA) and total cholesterol and PFUAand interleukin-6. PFAS concentrations were not associated with CIMT. Conclusion: PFHxS levels were elevated in firefighters compared toNHANES subjects. Serum PFAS concentrations were not associated with increased cardiometabolic risk measures in this population of firefighters.",

keywords = "National Health and Nutrition Examination Survey (NHANES), cardiometabolic, cardiovascular, carotid intima-media thickness (CIMT), firefighters, markers, per-and polyfluoroalkyl substances (PFAS)",

author = "Naila Khalil and Ducatman, {Alan M.} and Shripad Sinari and Dean Billheimer and Chengcheng Hu and Sally Littau and Burgess, {Jefferey L.}",

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AU - Khalil, Naila

AU - Ducatman, Alan M.

AU - Sinari, Shripad

AU - Billheimer, Dean

AU - Hu, Chengcheng

AU - Littau, Sally

AU - Burgess, Jefferey L.

PY - 2020/12

Y1 - 2020/12

N2 - Objective: To evaluate if serum polyfluoroalkyl substances (PFAS) wereassociated with cardiometabolic markers. Methods: Serum PFAS wereevaluated in 38 Arizona firefighters and 49 participants from the 2009 to2010 National Health and Nutrition Examination Survey (NHANES). Cardiometabolic markers including carotid intima-medial thickness (CIMT) were measured in the firefighters. Results: Firefighters had elevated perfluorohexanesulfonic acid (PFHxS) and lower perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) compared to NHANESparticipants; for nine of the other 12 PFAS the values were not significantlydifferent. There were significant negative associations among firefightersbetween perfluorodecanoic acid (PFDeA) and total cholesterol and PFUAand interleukin-6. PFAS concentrations were not associated with CIMT. Conclusion: PFHxS levels were elevated in firefighters compared toNHANES subjects. Serum PFAS concentrations were not associated with increased cardiometabolic risk measures in this population of firefighters.

AB - Objective: To evaluate if serum polyfluoroalkyl substances (PFAS) wereassociated with cardiometabolic markers. Methods: Serum PFAS wereevaluated in 38 Arizona firefighters and 49 participants from the 2009 to2010 National Health and Nutrition Examination Survey (NHANES). Cardiometabolic markers including carotid intima-medial thickness (CIMT) were measured in the firefighters. Results: Firefighters had elevated perfluorohexanesulfonic acid (PFHxS) and lower perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) compared to NHANESparticipants; for nine of the other 12 PFAS the values were not significantlydifferent. There were significant negative associations among firefightersbetween perfluorodecanoic acid (PFDeA) and total cholesterol and PFUAand interleukin-6. PFAS concentrations were not associated with CIMT. Conclusion: PFHxS levels were elevated in firefighters compared toNHANES subjects. Serum PFAS concentrations were not associated with increased cardiometabolic risk measures in this population of firefighters.

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KW - cardiovascular

KW - carotid intima-media thickness (CIMT)

KW - firefighters

KW - markers

KW - per-and polyfluoroalkyl substances (PFAS)

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Per-and polyfluoroalkyl substance and cardio metabolic markers in firefighters

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