Abstract
Recent studies have indicated that the most important role of β-amyloid peptide (Aβ) in the etiology of Alzheimer's disease may not be in plaque formation but in the formation of soluble, metastable Aβ 1-42 neurotoxic intermediates (called ADDLs). In the present work we describe the preparation of per-6-amino-6-deoxy-β-cyclodextrins, which inhibit ADDLs formation in vitro.
Original language | English (US) |
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Pages (from-to) | 3329-3333 |
Number of pages | 5 |
Journal | Journal of Medicinal Chemistry |
Volume | 47 |
Issue number | 13 |
DOIs | |
State | Published - Jun 17 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery