Peptidomimetics, a synthetic tool of drug discovery

Josef Vagner; Hongchang Qu; Victor J. Hruby

doi:10.1016/j.cbpa.2008.03.009

Peptidomimetics, a synthetic tool of drug discovery

Josef Vagner, Hongchang Qu, Victor J. Hruby

Research output: Contribution to journal › Review article › peer-review

474 Scopus citations

Abstract

The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.

Original language	English (US)
Pages (from-to)	292-296
Number of pages	5
Journal	Current Opinion in Chemical Biology
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.cbpa.2008.03.009
State	Published - Jun 2008

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1016/j.cbpa.2008.03.009

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title = "Peptidomimetics, a synthetic tool of drug discovery",

abstract = "The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.",

author = "Josef Vagner and Hongchang Qu and Hruby, {Victor J.}",

year = "2008",

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AU - Qu, Hongchang

AU - Hruby, Victor J.

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AB - The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.

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Peptidomimetics, a synthetic tool of drug discovery

Abstract

ASJC Scopus subject areas

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