Peptidomimetics, a synthetic tool of drug discovery

Josef Vagner, Hongchang Qu, Victor J. Hruby

Research output: Contribution to journalReview articlepeer-review

447 Scopus citations


The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.

Original languageEnglish (US)
Pages (from-to)292-296
Number of pages5
JournalCurrent Opinion in Chemical Biology
Issue number3
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


Dive into the research topics of 'Peptidomimetics, a synthetic tool of drug discovery'. Together they form a unique fingerprint.

Cite this