Peptide and peptidomimetic libraries: Molecular diversity and drug design

Fahad Al-Obeidi, Victor J. Hruby, Tomi K. Sawyer

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Various techniques for generation of peptide and peptidomimetic libraries are summarized in this article. Multipin, tea bag, and split- couple-mix techniques represent the major methods used to make peptides and peptidomimetics libraries. The synthesis of these libraries were made in either discrete or mixture format. Peptides and peptidomimetics combinatorial libraries were screened to discover leads against a variety of targets. These targets, including bacteria, fungus, virus, receptors, and enzymes were used in the screening of the libraries. Discovered leads can be further optimized by combinatorial approaches.

Original languageEnglish (US)
Pages (from-to)205-223
Number of pages19
JournalApplied Biochemistry and Biotechnology - Part B Molecular Biotechnology
Issue number3
StatePublished - 1998


  • Combinatorial libraries
  • Molecular diversity
  • Peptides
  • Peptidomimetics

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology


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