Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT

Raza Mushtaq; Matthew D. Kay; Laura Steinmeyer; Devdutta Warhadpande; Phillip H. Kuo

doi:10.1097/RLU.0000000000003183

Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT

Raza Mushtaq
, Matthew D. Kay
, Laura Steinmeyer
, Devdutta Warhadpande
, Phillip H. Kuo

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Dopamine transporter SPECT with 123I-N-?-fluoropropyl-2ß-carbomethoxy-3ß-(4-iodophenyl) nortropane (123I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient variation and vascular disease.

Original language	English (US)
Pages (from-to)	e469-e476
Journal	Clinical nuclear medicine
Volume	45
Issue number	11
DOIs	https://doi.org/10.1097/RLU.0000000000003183
State	Published - Nov 1 2020

Keywords

I-ioflupane
SPECT
dopamine transporter
parkinsonism
quantification

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/RLU.0000000000003183

Cite this

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title = "Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT",

abstract = "Dopamine transporter SPECT with 123I-N-?-fluoropropyl-2{\ss}-carbomethoxy-3{\ss}-(4-iodophenyl) nortropane (123I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient variation and vascular disease.",

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AU - Mushtaq, Raza

AU - Kay, Matthew D.

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AU - Kuo, Phillip H.

PY - 2020/11/1

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N2 - Dopamine transporter SPECT with 123I-N-?-fluoropropyl-2ß-carbomethoxy-3ß-(4-iodophenyl) nortropane (123I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient variation and vascular disease.

AB - Dopamine transporter SPECT with 123I-N-?-fluoropropyl-2ß-carbomethoxy-3ß-(4-iodophenyl) nortropane (123I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient variation and vascular disease.

KW - I-ioflupane

KW - SPECT

KW - dopamine transporter

KW - parkinsonism

KW - quantification

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Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT

Abstract

Keywords

ASJC Scopus subject areas

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