@article{ef6f458b6b9646a1bdf895c2c6dc2727,
title = "Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT",
abstract = "Dopamine transporter SPECT with 123I-N-?-fluoropropyl-2{\ss}-carbomethoxy-3{\ss}-(4-iodophenyl) nortropane (123I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient variation and vascular disease. ",
keywords = "I-ioflupane, SPECT, dopamine transporter, parkinsonism, quantification",
author = "Raza Mushtaq and Kay, {Matthew D.} and Laura Steinmeyer and Devdutta Warhadpande and Kuo, {Phillip H.}",
note = "Funding Information: Received for publication January 6, 2020; revision accepted May 14, 2020. From the *Department of Medical Imaging, University of Arizona College of Medicine; and †Department of Medicine and Biomedical Engineering, Uni-versity of Arizona, Tucson, AZ. Conflicts of interest and sources of funding: P.H.K. is a speaker, consultant, and recipient of grants from GE Healthcare. He is also a consultant for Invicro. The remaining authors have no conflicts of interest to disclose. Correspondence to: Matthew D. Kay, MBBS, Department of Medical Imaging, University of Arizona College of Medicine, 1501 N Campbell Ave, Tucson, AZ 85724. E-mail: mkay@radiology.arizona.edu. Copyright {\textcopyright} 2020 Wolters Kluwer Health, Inc. All rights reserved. ISSN: 0363-9762/20/4511–e469 DOI: 10.1097/RLU.0000000000003183 Publisher Copyright: {\textcopyright} Wolters Kluwer Health, Inc. All rights reserved.",
year = "2020",
month = nov,
day = "1",
doi = "10.1097/RLU.0000000000003183",
language = "English (US)",
volume = "45",
pages = "e469--e476",
journal = "Clinical Nuclear Medicine",
issn = "0363-9762",
publisher = "Lippincott Williams and Wilkins",
number = "11",
}