Pearls and Pitfalls of Quantitative Software Analysis of Dopamine Transporter SPECT

Raza Mushtaq, Matthew D. Kay, Laura Steinmeyer, Devdutta Warhadpande, Phillip H. Kuo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Dopamine transporter SPECT with 123I-N-?-fluoropropyl-2ß-carbomethoxy-3ß-(4-iodophenyl) nortropane (123I-ioflupane) aids in the diagnosis of parkinsonian syndrome by demonstrating loss of striatal dopamine transporters, proportional to nigrostriatal dopaminergic neuronal loss. Quantitative software analysis (QSA) is a helpful adjunct to visual interpretation. An atlas of pearls and pitfalls of QSA is presented. Examples include correction for head tilt/orientation, scaling artifacts, and detection of balanced loss of activity. Additional examples are provided where QSA can potentially fail such as patient variation and vascular disease.

Original languageEnglish (US)
Pages (from-to)e469-e476
JournalClinical nuclear medicine
Issue number11
StatePublished - Nov 1 2020


  • I-ioflupane
  • dopamine transporter
  • parkinsonism
  • quantification

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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