PDE5 inhibition rescues mitochondrial dysfunction and angiogenic responses induced by akt3 inhibition by promotion of PRC expression

Keyphrases

• Angiogenesis 100%
• Angiogenic Response 100%
• Mitochondrial Dysfunction 100%
• AKT3 100%
• PDE5 Inhibitors 100%
• Mitochondrial Homeostasis 71%
• Sildenafil 57%
• Peroxisome Proliferator-activated Receptor-γ coactivator-1α (PGC-1α) 57%
• Mitochondrial Function 28%
• Mitochondrial Biogenesis 28%
• Oxygen Consumption 28%
• Endothelial Cells 14%
• Protein Expression 14%
• Mitochondria 14%
• Master Regulator 14%
• Specificity Protein 1 14%
• Transcriptional Repressor 14%
• Pharmacological Inhibitors 14%
• Primary Endothelial Cells 14%
• Fission 14%
• Family Members 14%
• Heat Shock Protein 60 (HSP60) 14%
• Membrane Potential 14%
• Direct Inhibitors 14%
• Functional Links 14%
• Voltage-dependent Anion Channel 14%
• Nuclear Localization 14%
• PGC-1 14%
• CREB Transcription Factor 14%
• Paraquat 14%
• Protein Chaperone 14%
• Content-dependent 14%
• Mitochondrial Content 14%
• Mitochondrion-specific 14%
• Hsp10 14%
• Phosphodiesterase Type 5 Inhibitors 14%
• Mitochondrial DNA Content 14%
• Mitochondrial Stress 14%

Biochemistry, Genetics and Molecular Biology

• Angiogenesis 100%
• Homeostasis 71%
• Mitochondrion 28%
• Oxygen Consumption 28%
• Mitochondrial Biogenesis 28%
• Protein Expression 14%
• Cyclic Adenosine Monophosphate 14%
• Transcription Factors 14%
• Transcriptional Activator 14%
• Phosphodiesterase 14%
• HSP60 14%
• Membrane Potential 14%
• Mitochondrial DNA 14%
• DNA Content 14%
• Channel Protein 14%
• Voltage-Dependent Anion Channel 14%
• Chaperone (Protein) 14%
• CREB 14%