Pattern of failure following chemoradiation for locally advanced non-small cell lung cancer: Potential role for stereotactic body radiotherapy

Nam P. Nguyen; Maria Bishop; Thomas J. Borok; James Welsh; Russ Hamilton; Deirdre Cohen; L. Y.M. Nguyen; Vinh Hung Vincent

Pattern of failure following chemoradiation for locally advanced non-small cell lung cancer: Potential role for stereotactic body radiotherapy

Nam P. Nguyen, Maria Bishop, Thomas J. Borok, James Welsh, Russ Hamilton, Deirdre Cohen, L. Y.M. Nguyen, Vinh Hung Vincent

Radiation Oncology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Standard of care for locally advanced non-small cell lung cancer has been concurrent chemoradiation. However, optimal chemotherapy regimen, radiation therapy dose and treatment volume have not been clearly defined despite 30 years of controlled clinical trials. This review analyzes survival and failure pattern reported from randomized studies of chemoradiation for non-small cell lung cancer. Despite introduction of new chemotherapy agents, survival remained poor; rates of both locoregional failures and distant metastasis remained high. The current radiation dose appears insufficient to reliably establish local control. Stereotactic body radiotherapy may allow radiation dose escalation and should be tested in future clinical trials.

Original language	English (US)
Pages (from-to)	953-962
Number of pages	10
Journal	Anticancer research
Volume	30
Issue number	3
State	Published - Mar 2010

Keywords

Chemoradiation
Locally advanced
Non-small cell lung cancer
Pattern of failure

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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abstract = "Standard of care for locally advanced non-small cell lung cancer has been concurrent chemoradiation. However, optimal chemotherapy regimen, radiation therapy dose and treatment volume have not been clearly defined despite 30 years of controlled clinical trials. This review analyzes survival and failure pattern reported from randomized studies of chemoradiation for non-small cell lung cancer. Despite introduction of new chemotherapy agents, survival remained poor; rates of both locoregional failures and distant metastasis remained high. The current radiation dose appears insufficient to reliably establish local control. Stereotactic body radiotherapy may allow radiation dose escalation and should be tested in future clinical trials.",

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AU - Nguyen, Nam P.

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AU - Welsh, James

AU - Hamilton, Russ

AU - Cohen, Deirdre

AU - Nguyen, L. Y.M.

AU - Vincent, Vinh Hung

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AB - Standard of care for locally advanced non-small cell lung cancer has been concurrent chemoradiation. However, optimal chemotherapy regimen, radiation therapy dose and treatment volume have not been clearly defined despite 30 years of controlled clinical trials. This review analyzes survival and failure pattern reported from randomized studies of chemoradiation for non-small cell lung cancer. Despite introduction of new chemotherapy agents, survival remained poor; rates of both locoregional failures and distant metastasis remained high. The current radiation dose appears insufficient to reliably establish local control. Stereotactic body radiotherapy may allow radiation dose escalation and should be tested in future clinical trials.

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Pattern of failure following chemoradiation for locally advanced non-small cell lung cancer: Potential role for stereotactic body radiotherapy

Abstract

Keywords

ASJC Scopus subject areas

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