Pathophysiology of tumour-induced microangiopathic haemolytic anaemia

Pavani Chalasani; Jennifer M. Segar; Marilyn Marron; Alison Stopeck

doi:10.1136/bcr-2015-213521

Pathophysiology of tumour-induced microangiopathic haemolytic anaemia

Pavani Chalasani, Jennifer M. Segar, Marilyn Marron, Alison Stopeck

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Cancer-associated microangiopathic haemolytic anaemia (CA-MAHA) is a syndrome characterised by Coombsnegative haemolytic anaemia and thrombocytopenia. It is primarily seen in advanced solid tumours and is distinct from thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome. Diagnosis is often delayed and patients have a high mortality. We present the case of CA-MAHA in a patient with metastatic breast cancer treated successfully with early initiation of chemotherapy. In addition, we report longitudinal laboratory evaluation of circulating tumour cells and microparticles and suggest a hypothesis for the mechanism behind CAMAHA.

Original language	English (US)
Article number	213521
Journal	BMJ case reports
Volume	2016
DOIs	https://doi.org/10.1136/bcr-2015-213521
State	Published - Jan 7 2016

ASJC Scopus subject areas

General Medicine

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title = "Pathophysiology of tumour-induced microangiopathic haemolytic anaemia",

abstract = "Cancer-associated microangiopathic haemolytic anaemia (CA-MAHA) is a syndrome characterised by Coombsnegative haemolytic anaemia and thrombocytopenia. It is primarily seen in advanced solid tumours and is distinct from thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome. Diagnosis is often delayed and patients have a high mortality. We present the case of CA-MAHA in a patient with metastatic breast cancer treated successfully with early initiation of chemotherapy. In addition, we report longitudinal laboratory evaluation of circulating tumour cells and microparticles and suggest a hypothesis for the mechanism behind CAMAHA.",

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AU - Chalasani, Pavani

AU - Segar, Jennifer M.

AU - Marron, Marilyn

AU - Stopeck, Alison

PY - 2016/1/7

Y1 - 2016/1/7

N2 - Cancer-associated microangiopathic haemolytic anaemia (CA-MAHA) is a syndrome characterised by Coombsnegative haemolytic anaemia and thrombocytopenia. It is primarily seen in advanced solid tumours and is distinct from thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome. Diagnosis is often delayed and patients have a high mortality. We present the case of CA-MAHA in a patient with metastatic breast cancer treated successfully with early initiation of chemotherapy. In addition, we report longitudinal laboratory evaluation of circulating tumour cells and microparticles and suggest a hypothesis for the mechanism behind CAMAHA.

AB - Cancer-associated microangiopathic haemolytic anaemia (CA-MAHA) is a syndrome characterised by Coombsnegative haemolytic anaemia and thrombocytopenia. It is primarily seen in advanced solid tumours and is distinct from thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome. Diagnosis is often delayed and patients have a high mortality. We present the case of CA-MAHA in a patient with metastatic breast cancer treated successfully with early initiation of chemotherapy. In addition, we report longitudinal laboratory evaluation of circulating tumour cells and microparticles and suggest a hypothesis for the mechanism behind CAMAHA.

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Pathophysiology of tumour-induced microangiopathic haemolytic anaemia

Abstract

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