Pathology of experimental African trypanosomiasis in rabbits infected with Trypanosoma rhodesiense

R. B. Nagle, S. Dong, J. M. Guillot, K. M. McDaniel, H. B. Lindsley

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The pathologic response of New Zealand White rabbits to experimental infection with Trypansoma rhodesiense is described. Autopsies of 18 rabbits killed from 30-44 days after infection revealed focal perivascular inflammation of the ears, eyes, and testes. Examination by electron microscopy revealed extravascular trypanosomes in the dermis of the ear and interstitium of testes. Deposits of IgG, IgM and C3 were in renal glomeruli associated with glomerular hypercellularity; proteinuria was present as evidenced by an increase in tubular hyaline droplets. There was marked hyperplasia of lymph nodes and spleen with generalized increase in the number of macrophage and plasma cells. In contrast there was thymic atrophy. The findings suggest an immunologic host repsonse associated with severe localized vascular injury.

Original languageEnglish (US)
Pages (from-to)1187-1195
Number of pages9
JournalUnknown Journal
Issue number6
StatePublished - 1980

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases


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