Pathology of experimental African trypanosomiasis in rabbits infected with Trypanosoma rhodesiense

R. B. Nagle; S. Dong; J. M. Guillot; K. M. McDaniel; H. B. Lindsley

doi:10.4269/ajtmh.1980.29.1187

Pathology of experimental African trypanosomiasis in rabbits infected with Trypanosoma rhodesiense

R. B. Nagle, S. Dong, J. M. Guillot, K. M. McDaniel, H. B. Lindsley

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9 Scopus citations

Abstract

The pathologic response of New Zealand White rabbits to experimental infection with Trypansoma rhodesiense is described. Autopsies of 18 rabbits killed from 30-44 days after infection revealed focal perivascular inflammation of the ears, eyes, and testes. Examination by electron microscopy revealed extravascular trypanosomes in the dermis of the ear and interstitium of testes. Deposits of IgG, IgM and C3 were in renal glomeruli associated with glomerular hypercellularity; proteinuria was present as evidenced by an increase in tubular hyaline droplets. There was marked hyperplasia of lymph nodes and spleen with generalized increase in the number of macrophage and plasma cells. In contrast there was thymic atrophy. The findings suggest an immunologic host repsonse associated with severe localized vascular injury.

Original language	English (US)
Pages (from-to)	1187-1195
Number of pages	9
Journal	Unknown Journal
Volume	29
Issue number	6
DOIs	https://doi.org/10.4269/ajtmh.1980.29.1187
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Infectious Diseases
Virology

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10.4269/ajtmh.1980.29.1187

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title = "Pathology of experimental African trypanosomiasis in rabbits infected with Trypanosoma rhodesiense",

abstract = "The pathologic response of New Zealand White rabbits to experimental infection with Trypansoma rhodesiense is described. Autopsies of 18 rabbits killed from 30-44 days after infection revealed focal perivascular inflammation of the ears, eyes, and testes. Examination by electron microscopy revealed extravascular trypanosomes in the dermis of the ear and interstitium of testes. Deposits of IgG, IgM and C3 were in renal glomeruli associated with glomerular hypercellularity; proteinuria was present as evidenced by an increase in tubular hyaline droplets. There was marked hyperplasia of lymph nodes and spleen with generalized increase in the number of macrophage and plasma cells. In contrast there was thymic atrophy. The findings suggest an immunologic host repsonse associated with severe localized vascular injury.",

author = "Nagle, {R. B.} and S. Dong and Guillot, {J. M.} and McDaniel, {K. M.} and Lindsley, {H. B.}",

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T1 - Pathology of experimental African trypanosomiasis in rabbits infected with Trypanosoma rhodesiense

AU - Nagle, R. B.

AU - Dong, S.

AU - Guillot, J. M.

AU - McDaniel, K. M.

AU - Lindsley, H. B.

PY - 1980

Y1 - 1980

N2 - The pathologic response of New Zealand White rabbits to experimental infection with Trypansoma rhodesiense is described. Autopsies of 18 rabbits killed from 30-44 days after infection revealed focal perivascular inflammation of the ears, eyes, and testes. Examination by electron microscopy revealed extravascular trypanosomes in the dermis of the ear and interstitium of testes. Deposits of IgG, IgM and C3 were in renal glomeruli associated with glomerular hypercellularity; proteinuria was present as evidenced by an increase in tubular hyaline droplets. There was marked hyperplasia of lymph nodes and spleen with generalized increase in the number of macrophage and plasma cells. In contrast there was thymic atrophy. The findings suggest an immunologic host repsonse associated with severe localized vascular injury.

AB - The pathologic response of New Zealand White rabbits to experimental infection with Trypansoma rhodesiense is described. Autopsies of 18 rabbits killed from 30-44 days after infection revealed focal perivascular inflammation of the ears, eyes, and testes. Examination by electron microscopy revealed extravascular trypanosomes in the dermis of the ear and interstitium of testes. Deposits of IgG, IgM and C3 were in renal glomeruli associated with glomerular hypercellularity; proteinuria was present as evidenced by an increase in tubular hyaline droplets. There was marked hyperplasia of lymph nodes and spleen with generalized increase in the number of macrophage and plasma cells. In contrast there was thymic atrophy. The findings suggest an immunologic host repsonse associated with severe localized vascular injury.

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Pathology of experimental African trypanosomiasis in rabbits infected with Trypanosoma rhodesiense

Abstract

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