Past and Future Episodic Detail Retrieval Is Reduced Among Clinically Normal Older Adults at Higher Genetic Risk for Late-Onset Alzheimer’s Disease

Mónica C. Acevedo-Molina, Sean C. Thayer, Kiley Horn, Hanna Nkulu, Lee Ryan, Jessica R. Andrews-Hanna, Matthew D. Grilli

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: Remembering and imagining personal events that are rich in episodic (i.e., event-specific) detail is compromised in older adults who have mild cognitive impairment, a known risk factor for Alzheimer’s disease dementia. Less clear is whether lower episodic detail generation is associated with higher risk for Alzheimer’s disease dementia before mild clinical decline is detectable. Method: We compared past and future autobiographical thinking in clinically normal older adult carriers of the Alzheimer’s diseaseassociated apolipoprotein E e4 allele (APOE4; n = 39) to demographically and neuropsychologically similar non-APOE4 carriers (n = 43). Results: APOE4 carriers showed a significant reduction for episodic details when remembering past events (d =.47) and imagining future events (d =.46), but not for nonepisodic details. Conclusions: These findings suggest that APOE4 is associated with a selective reduction of episodic detail during past and future autobiographical thinking among clinically normal older adults.

Original languageEnglish (US)
Pages (from-to)194-203
Number of pages10
JournalNeuropsychology
Volume37
Issue number2
DOIs
StatePublished - Nov 28 2022

Keywords

  • aging
  • apolipoprotein E
  • autobiographical memory
  • future thinking
  • neuropsychology

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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