Abstract
Objective: Remembering and imagining personal events that are rich in episodic (i.e., event-specific) detail is compromised in older adults who have mild cognitive impairment, a known risk factor for Alzheimer’s disease dementia. Less clear is whether lower episodic detail generation is associated with higher risk for Alzheimer’s disease dementia before mild clinical decline is detectable. Method: We compared past and future autobiographical thinking in clinically normal older adult carriers of the Alzheimer’s diseaseassociated apolipoprotein E e4 allele (APOE4; n = 39) to demographically and neuropsychologically similar non-APOE4 carriers (n = 43). Results: APOE4 carriers showed a significant reduction for episodic details when remembering past events (d =.47) and imagining future events (d =.46), but not for nonepisodic details. Conclusions: These findings suggest that APOE4 is associated with a selective reduction of episodic detail during past and future autobiographical thinking among clinically normal older adults.
Original language | English (US) |
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Pages (from-to) | 194-203 |
Number of pages | 10 |
Journal | Neuropsychology |
Volume | 37 |
Issue number | 2 |
DOIs | |
State | Published - Nov 28 2022 |
Keywords
- aging
- apolipoprotein E
- autobiographical memory
- future thinking
- neuropsychology
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology