Parasite–host cell interactions in toxoplasmosis: New avenues for intervention?

Isabelle Coppens, Keith A Joiner

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Toxoplasma gondii is a protozoan parasite that is uniquely adapted for penetrating and surviving within a wide range of host cells. This parasite invades mammalian cells by an active actin-dependent mechanism, and after entry establishes a vacuole with the assistance of products secreted by the parasite's apical organelles. Simultaneously, Toxoplasma sets about gaining access to cellular nutrients by forming pores in the vacuolar membrane. In this manner it enjoys a rich and comfortable lifestyle at the host cell's expense. Understanding the Toxoplasma–host interaction may reveal unusual mechanisms for exploiting host cell pathways and diverting host organelle functions. These novel modifications could also be potential targets for new drugs.

Original languageEnglish (US)
Pages (from-to)1-20
Number of pages20
JournalExpert Reviews in Molecular Medicine
Issue number2
StatePublished - Jan 15 2001


  • Toxoplasma gondii
  • host cell manipulation
  • intracellular protozoan
  • nutrition
  • parasitophorous vacuole

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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