Parasite potpourri: Toxoplasma gondii lineage tracing in vivo

Anita A. Koshy

doi:10.1016/j.pt.2022.10.002

Parasite potpourri: Toxoplasma gondii lineage tracing in vivo

Anita A. Koshy

Research output: Contribution to journal › Short survey › peer-review

Abstract

Using a CRISPR/Cas9-based method, Wincott et al. generated a stable, complex Toxoplasma gondii population composed of 96 barcoded clonal lineages. By tracking the population structure in vivo, they determine that – contrary to expectations – the pathway to infecting the brain is widely permissive for T. gondii.

Original language	English (US)
Pages (from-to)	1026-1027
Number of pages	2
Journal	Trends in Parasitology
Volume	38
Issue number	12
DOIs	https://doi.org/10.1016/j.pt.2022.10.002
State	Published - Dec 2022
Externally published	Yes

Keywords

Toxoplasma gondii
blood–brain barrier
dissemination
genetic bottleneck
molecular barcode

ASJC Scopus subject areas

Parasitology
Infectious Diseases

Access to Document

10.1016/j.pt.2022.10.002

Cite this

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title = "Parasite potpourri: Toxoplasma gondii lineage tracing in vivo",

abstract = "Using a CRISPR/Cas9-based method, Wincott et al. generated a stable, complex Toxoplasma gondii population composed of 96 barcoded clonal lineages. By tracking the population structure in vivo, they determine that – contrary to expectations – the pathway to infecting the brain is widely permissive for T. gondii.",

keywords = "Toxoplasma gondii, blood–brain barrier, dissemination, genetic bottleneck, molecular barcode",

author = "Koshy, \{Anita A.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = dec,

doi = "10.1016/j.pt.2022.10.002",

language = "English (US)",

volume = "38",

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journal = "Trends in Parasitology",

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TY - JOUR

T1 - Parasite potpourri

T2 - Toxoplasma gondii lineage tracing in vivo

AU - Koshy, Anita A.

PY - 2022/12

Y1 - 2022/12

N2 - Using a CRISPR/Cas9-based method, Wincott et al. generated a stable, complex Toxoplasma gondii population composed of 96 barcoded clonal lineages. By tracking the population structure in vivo, they determine that – contrary to expectations – the pathway to infecting the brain is widely permissive for T. gondii.

AB - Using a CRISPR/Cas9-based method, Wincott et al. generated a stable, complex Toxoplasma gondii population composed of 96 barcoded clonal lineages. By tracking the population structure in vivo, they determine that – contrary to expectations – the pathway to infecting the brain is widely permissive for T. gondii.

KW - Toxoplasma gondii

KW - blood–brain barrier

KW - dissemination

KW - genetic bottleneck

KW - molecular barcode

UR - https://www.scopus.com/pages/publications/85140402190

UR - https://www.scopus.com/pages/publications/85140402190#tab=citedBy

U2 - 10.1016/j.pt.2022.10.002

DO - 10.1016/j.pt.2022.10.002

M3 - Short survey

C2 - 36302693

AN - SCOPUS:85140402190

SN - 1471-4922

VL - 38

SP - 1026

EP - 1027

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 12

ER -

Parasite potpourri: Toxoplasma gondii lineage tracing in vivo

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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