Paraneoplastic temporal lobe epilepsy with testicular neoplasm and atypical amnesia

Geoffrey L. Ahern, M. O’Connor, J. Dalmau, A. Coleman, J. B. Posner, D. L. Schomer, A. G. Herzog, D. A. Kolb, M. M. Mesulam

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


We report a patient who, at age 38, presented with temporal lobe seizures andanatypicalmemory disorder 3 years before the discovery of a testicular tumor. Detailedneuropsychological testing revealed a relatively isolated amnestic syndrome. The amnesia wasatypicalas the patient could retain information for hour-long periods, only to lose it later. Serologic studies revealed the presence of a circulating autoantibody that demonstrated anunusual affinity for the nucleolus of cerebral cortical neurons. Western blot analysis ofcortical neurons revealed that this antibody reacted with proteins different from otherpreviously identified paraneoplastic neurologic antigens (Hu, Yo, Ri). We believe thistobe acase of paraneoplastic limbic encephalitis secondary to the testicular tumor. This patient presents unique characteristics with respect to the mode of presentation, featuresof the amnesia, and the presence of a circulating antibody with an unusual reactivity pattern.

Original languageEnglish (US)
Pages (from-to)1270-1274
Number of pages5
Issue number7
StatePublished - Jul 1994

ASJC Scopus subject areas

  • Clinical Neurology


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