Paracoccidioidomycosis (South American blastomycosis): Treatment with miconazole

D. A. Stevens, A. Restrepo-M, A. Cortés, J. Betancourt, J. N. Galgiani, I. Gómez

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Six patients with multisystem paracoccidioidomycosis proven by serology and culture or smear were treated with relatively brief courses of intravenous miconazole. Two had relapsed following prior therapy; 6 had active pulmonary, 4 laryngeal, 2 oropharyngeal, 2 lymphoid, and 1 abdominal disease. Paracoccidioides brasiliensis was highly susceptible to miconazole in vitro; minimal inhibitory concentration was ≤ 0.001 μg/ml. Clinical examination showed a prompt and objective response in all patients, confirmed by smear or culture and X-rays; in 4/6 serological response was shown. Side effect were minor. Two patients relapsed 3-5 mo after therapy; another had a rise in antibody 6 mo after therapy and was given maintenance oral sulfa. One remains in remssion 7 mo after treatment; two given oral sulfa after response to miconazole remain in remission 4-6 mo after treatment. Paracoccidioidomycosis responds well to miconazole, but longer courses may be needed to prevent relapse.

Original languageEnglish (US)
Pages (from-to)801-807
Number of pages7
JournalUnknown Journal
Issue number4
StatePublished - 1978

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases


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