Pantailocins: phage-derived bacteriocins from Pantoea ananatis and Pantoea stewartii subsp. indologenes

Shaun P. Stice, Hsiao Hsuan Jan, Hsiao Chun Chen, Linda Nwosu, Gi Yoon Shin, Savannah Weaver, Teresa Coutinho, Brian H. Kvitko, David A. Baltrus

Research output: Contribution to journalArticlepeer-review

Abstract

Phage-derived bacteriocins are highly specific and effective antimicrobial molecules, which have successfully been used as prophylactic treatments to prevent phytopathogen infections. Given the specificity of tailocins, a necessary step for broadening the tailocin catalog and for extending applicability across systems and diseases is the screening of new clades of phytopathogens for the production of molecules with tailocin-like killing activity. Here, we describe the production by and sensitivity of strains to tailocins produced by Pantoea ananatis and Pantoea stewartii subsp. indologenes. Phylogenetic evidence suggests that these tailocins are derived from Myoviridae family phage like many previously described R-type tailocins but also suggests that cooption from phage occurred independently of previously described tailocins. Since these tailocin encoding loci are present in the same genomic locations across multiple strains of both species and display a level of divergence that is consistent with other shared regions between the genomes and with vertical inheritance of the locus, we refer to them broadly as “Pantailocins.”

Original languageEnglish (US)
Article numbere00929-23
JournalApplied and environmental microbiology
Volume89
Issue number12
DOIs
StatePublished - Dec 2023

Keywords

  • Pantoea ananatis
  • Pantoea stewartii
  • phage-derived bacteriocin
  • tailocins

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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