Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy

Alejandro Garcia-Uribe, Cheng Chung Chang, Jun Zou, Bhaskar Banerjee, John Kuczynski, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


In surgical treatment of pancreatic cancers, the effectiveness of the procedures largely depends on the ability to completely and precisely remove the malignant tumors. We present the ex-vivo use of oblique incidence diffuse reflectance spectroscopy (OIRDS) to detect and differentiate normal from neoplastic tissue. An OIRDS probe has been constructed to provide scattering and absorption information of the pancreatic tissue. To reveal the physiological origin of the difference in these optical signatures, the optical scattering coefficients were extracted along the pancreatic duct with 1-cm spacing. Experimental results show that OIDRS was able to successfully determinate the tumor margins based on the higher optical scattering on malignant tissue.

Original languageEnglish (US)
Title of host publicationOptical Biopsy IX
ISBN (Print)9780819484321
StatePublished - Feb 16 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


  • cancer
  • diffuse reflectance
  • scattering
  • spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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