TY - JOUR
T1 - Pancreas transplantation in the United States
T2 - A review
AU - Gruessner, Angelika C.
AU - Sutherland, David E.R.
AU - Gruessner, Rainer W.G.
PY - 2010/2
Y1 - 2010/2
N2 - Purpose of review: The goal of pancreas transplantation is to restore normoglycemia in patients with labile diabetes. The results of this procedure improved over the years, but, although pancreas transplantation is not considered experimental anymore, there is often reluctance to recommend this procedure because of the complexity, especially for solitary pancreas transplants. This article reviews the current status of pancreas transplantation. Recent findings: Many improvements have been made in the surgical techniques and immunosuppressive regimens. The overall rate of technical problems decreased, yet immunologic graft loss is still a problem in solitary pancreas transplants. Careful donor selection significantly decreased the risk of graft failure and therefore improved patient survival. Summary: With modern immunosuppressive protocols and careful donor selection, patient survival rates and pancreas transplant graft function can be further improved in all three pancreas transplant categories.
AB - Purpose of review: The goal of pancreas transplantation is to restore normoglycemia in patients with labile diabetes. The results of this procedure improved over the years, but, although pancreas transplantation is not considered experimental anymore, there is often reluctance to recommend this procedure because of the complexity, especially for solitary pancreas transplants. This article reviews the current status of pancreas transplantation. Recent findings: Many improvements have been made in the surgical techniques and immunosuppressive regimens. The overall rate of technical problems decreased, yet immunologic graft loss is still a problem in solitary pancreas transplants. Careful donor selection significantly decreased the risk of graft failure and therefore improved patient survival. Summary: With modern immunosuppressive protocols and careful donor selection, patient survival rates and pancreas transplant graft function can be further improved in all three pancreas transplant categories.
KW - Graft function
KW - Immunologic graft loss
KW - Pancreas transplantation
KW - Patient survival
UR - http://www.scopus.com/inward/record.url?scp=75749121116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75749121116&partnerID=8YFLogxK
U2 - 10.1097/MOT.0b013e32833552d2
DO - 10.1097/MOT.0b013e32833552d2
M3 - Review article
C2 - 20009932
AN - SCOPUS:75749121116
SN - 1087-2418
VL - 15
SP - 93
EP - 101
JO - Current Opinion in Organ Transplantation
JF - Current Opinion in Organ Transplantation
IS - 1
ER -