@article{ac2dde39e9e34421bea25d44d85222a9,
title = "Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment",
abstract = "Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics across different cancer types. Here, we perform pan-cancer analysis on 226 samples across 10 solid cancer types to profile the TME at single-cell resolution, illustrating the commonalities/plasticity of heterogenous CAFs. Activation trajectory of the major CAF types is divided into three states, exhibiting distinct interactions with other cell components, and relating to prognosis of immunotherapy. Moreover, minor CAF components represent the alternative origin from other TME components (e.g., endothelia and macrophages). Particularly, the ubiquitous presentation of endothelial-to-mesenchymal transition CAF, which may interact with proximal SPP1+ tumor-associated macrophages, is implicated in endothelial-to-mesenchymal transition and survival stratifications. Our study comprehensively profiles the shared characteristics and dynamics of CAFs, and highlight their heterogeneity and plasticity across different cancer types. Browser of integrated pan-cancer single-cell information is available at https://gist-fgl.github.io/sc-caf-atlas/.",
author = "Han Luo and Xuyang Xia and Huang, {Li Bin} and Hyunsu An and Minyuan Cao and Kim, {Gyeong Dae} and Chen, {Hai Ning} and Zhang, {Wei Han} and Yang Shu and Xiangyu Kong and Zhixiang Ren and Li, {Pei Heng} and Yang Liu and Huairong Tang and Ronghao Sun and Chao Li and Bing Bai and Weiguo Jia and Yi Liu and Wei Zhang and Li Yang and Yong Peng and Lunzhi Dai and Hongbo Hu and Yong Jiang and Yiguo Hu and Jingqiang Zhu and Hong Jiang and Zhihui Li and Carlos Caulin and Jihwan Park and Heng Xu",
note = "Funding Information: Appreciates the assistance of Mis. Xinyue Hu in illustration (Fig. ) design and drawing. This study was supported by the National Key R&D Program of China (No. 2021YFA1301203(H.X.), 2018YFC2000305(L.Z.D.)), National Natural Science Foundation of China (82103031(H.L.), 81973408(H.X.), 82272933 (H.L.), 82273445(Y.S.)), International Cooperation Project of Chengdu Municipal Science and Technology Bureau (2020-GH02-00017-HZ(H.L.)), 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (No. ZYYC20003(H.X.), ZYJC18035(H.L.), ZYJC18025(Z.H.L.), ZYJC18003(Y.L.), ZYJC18004(H.X.), and ZYYC20007(L.D.)), and the National Research Foundation of Korea funded by the Korean government (2019R1C1C1005403(J.P), 2019R1A4A1028802(J.P), 2021M3H9A2097520(J.P)), Clinical Research Incubation Project, West China Hospital, Sichuan University (22HXFH019(H.L)). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1038/s41467-022-34395-2",
language = "English (US)",
volume = "13",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}