Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry

Edita Navratilova; Jennifer Y. Xie; Alec Okun; Chaoling Qu; Nathan Eyde; Shuang Ci; Michael H. Ossipov; Tamara King; Howard L. Fields; Frank Porreca

doi:10.1073/pnas.1214605109

Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry

Edita Navratilova, Jennifer Y. Xie, Alec Okun, Chaoling Qu, Nathan Eyde, Shuang Ci, Michael H. Ossipov, Tamara King, Howard L. Fields, Frank Porreca

Research output: Contribution to journal › Article › peer-review

257 Scopus citations

Abstract

Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. The data directly support the hypothesis that relief of pain produces negative reinforcement through activation of the mesolimbic reward–valuation circuitry.

Original language	English (US)
Pages (from-to)	20709-20713
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	109
Issue number	50
DOIs	https://doi.org/10.1073/pnas.1214605109
State	Published - Dec 11 2012

Keywords

Immunohistochemistry
In vivo microdialysis
Incision
Motivated behavior
Ventral tegmental area

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.1214605109

Cite this

Navratilova, E., Xie, J. Y., Okun, A., Qu, C., Eyde, N., Ci, S., Ossipov, M. H., King, T., Fields, H. L., & Porreca, F. (2012). Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry. Proceedings of the National Academy of Sciences of the United States of America, 109(50), 20709-20713. https://doi.org/10.1073/pnas.1214605109

Navratilova, E, Xie, JY, Okun, A, Qu, C, Eyde, N, Ci, S, Ossipov, MH, King, T, Fields, HL & Porreca, F 2012, 'Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 50, pp. 20709-20713. https://doi.org/10.1073/pnas.1214605109

@article{d31193a6264e4da18d21b7bdd71ffe30,

title = "Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry",

abstract = "Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. The data directly support the hypothesis that relief of pain produces negative reinforcement through activation of the mesolimbic reward–valuation circuitry.",

keywords = "Immunohistochemistry, In vivo microdialysis, Incision, Motivated behavior, Ventral tegmental area",

author = "Edita Navratilova and Xie, {Jennifer Y.} and Alec Okun and Chaoling Qu and Nathan Eyde and Shuang Ci and Ossipov, {Michael H.} and Tamara King and Fields, {Howard L.} and Frank Porreca",

year = "2012",

month = dec,

day = "11",

doi = "10.1073/pnas.1214605109",

language = "English (US)",

volume = "109",

pages = "20709--20713",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "50",

}

TY - JOUR

T1 - Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry

AU - Navratilova, Edita

AU - Xie, Jennifer Y.

AU - Okun, Alec

AU - Qu, Chaoling

AU - Eyde, Nathan

AU - Ci, Shuang

AU - Ossipov, Michael H.

AU - King, Tamara

AU - Fields, Howard L.

AU - Porreca, Frank

PY - 2012/12/11

Y1 - 2012/12/11

N2 - Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. The data directly support the hypothesis that relief of pain produces negative reinforcement through activation of the mesolimbic reward–valuation circuitry.

AB - Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. The data directly support the hypothesis that relief of pain produces negative reinforcement through activation of the mesolimbic reward–valuation circuitry.

KW - Immunohistochemistry

KW - In vivo microdialysis

KW - Incision

KW - Motivated behavior

KW - Ventral tegmental area

UR - http://www.scopus.com/inward/record.url?scp=84874444262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874444262&partnerID=8YFLogxK

U2 - 10.1073/pnas.1214605109

DO - 10.1073/pnas.1214605109

M3 - Article

C2 - 23184995

AN - SCOPUS:84874444262

SN - 0027-8424

VL - 109

SP - 20709

EP - 20713

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 50

ER -

Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this