TY - JOUR
T1 - Pain, psychological variables, sleep quality, and natural killer cell activity in midlife women with and without fibromyalgia
AU - Landis, Carol A.
AU - Lentz, Martha J.
AU - Tsuji, Joyce
AU - Buchwald, Dedra
AU - Shaver, Joan L.F.
N1 - Funding Information:
We thank Ms. Darla Chapman, Ms. Stacey Riffle, and Ms. Diana McMillan for assistance with subject recruitment and Mr. James Rothermel and Mr. Josh McMillion for technical assistance in data collection, sleep scoring, and processing. We thank Ms. Diana Gates, Ms. Sophia Shiau, and Elizabeth Spitzer for assistance with sleep laboratory procedures and data collection. We also thank Ms. Stacy Riffle and Ms. Kristie Marbut for obtaining the blood samples and Ms. Susie Kozawa and Mr. David Reeder for blood sample processing. We also thank Dr. Beth Hacker and Mr. Rick Edwards for conducting the hormone assays. Finally, we acknowledge the work of Ms. Sandra Johnston in the preparation of the data for statistical analysis. This work was supported by National Institute of Nursing Research, Grants NR01118 (Cal) and NR04001 (Center for Womens Health Research).
PY - 2004/7
Y1 - 2004/7
N2 - In women with fibromyalgia (FM), central nervous system (CNS) dysfunction in pain, mood, and sleep processes could be associated with changes in immune system indicators. The primary purpose of this study was to compare pain, psychological variables, subjective and objective sleep quality, lymphocyte phenotypes and activation markers, and natural killer activity (NKA) in midlife women with and without FM. A secondary purpose was to explore relationships among these variables in a step-wise regression. Subjects had pain pressure tender points assessed, completed a psychiatric interview and questionnaires (Beck Depression Inventory, SCL-90, Profile of Mood States, subjective sleep), and underwent polysomnograhic assessment for two consecutive nights. Lymphocyte phenotypes, activation markers, and NKA were assessed from blood drawn the morning after sleep laboratory night 2. Compared to controls, women with FM had lower pain thresholds, more psychological distress, higher depression scores, and reduced subjective and objective sleep quality. They also had fewer NK cells (p<.009) and more NK cells that expressed the IL-2 receptor (p<.04), but these differences were not statistically significant after correction for multiple comparisons. NKA was not statistically significantly lower in the women with FM compared to controls. In a multiple regression of age, tender point threshold, depression, psychological distress, and sleep efficiency, only the effect of group was significant (F=5.479, p<.03) on NKA. In conclusion, we found little evidence to support the hypothesis that pain, mood, and sleep symptoms are associated with changes in the enumeration of peripheral lymphocytes or function in FM.
AB - In women with fibromyalgia (FM), central nervous system (CNS) dysfunction in pain, mood, and sleep processes could be associated with changes in immune system indicators. The primary purpose of this study was to compare pain, psychological variables, subjective and objective sleep quality, lymphocyte phenotypes and activation markers, and natural killer activity (NKA) in midlife women with and without FM. A secondary purpose was to explore relationships among these variables in a step-wise regression. Subjects had pain pressure tender points assessed, completed a psychiatric interview and questionnaires (Beck Depression Inventory, SCL-90, Profile of Mood States, subjective sleep), and underwent polysomnograhic assessment for two consecutive nights. Lymphocyte phenotypes, activation markers, and NKA were assessed from blood drawn the morning after sleep laboratory night 2. Compared to controls, women with FM had lower pain thresholds, more psychological distress, higher depression scores, and reduced subjective and objective sleep quality. They also had fewer NK cells (p<.009) and more NK cells that expressed the IL-2 receptor (p<.04), but these differences were not statistically significant after correction for multiple comparisons. NKA was not statistically significantly lower in the women with FM compared to controls. In a multiple regression of age, tender point threshold, depression, psychological distress, and sleep efficiency, only the effect of group was significant (F=5.479, p<.03) on NKA. In conclusion, we found little evidence to support the hypothesis that pain, mood, and sleep symptoms are associated with changes in the enumeration of peripheral lymphocytes or function in FM.
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U2 - 10.1016/j.bbi.2003.11.001
DO - 10.1016/j.bbi.2003.11.001
M3 - Article
C2 - 15157947
AN - SCOPUS:2442511747
SN - 0889-1591
VL - 18
SP - 304
EP - 313
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
IS - 4
ER -