P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair

Andrew N. Bankston; Wenqi Li; Hui Zhang; Li Ku; Guanglu Liu; Filomena Papa; Lixia Zhao; James A. Bibb; Franca Cambi; Seema K. Tiwari-Woodruff; Yue Feng

doi:10.1074/jbc.M113.453688

P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair

Andrew N. Bankston
, Wenqi Li
, Hui Zhang
, Li Ku
, Guanglu Liu
, Filomena Papa
, Lixia Zhao
, James A. Bibb
, Franca Cambi
, Seema K. Tiwari-Woodruff
, Yue Feng

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: Cyclin-dependent kinase 5 (Cdk5) is crucial for brain development. Results: In contrast to neurons that utilize p35 as the primary Cdk5 activator, oligodendroglia employ p39-dependent Cdk5 activation to advance differentiation and myelin repair. Conclusion: p39 is the primary Cdk5 activator in oligodendroglia, essential for oligodendroglia development. Significance: Our study revealed distinct mechanisms controlling Cdk5 activity in neurons and oligodendroglia.

Original language	English (US)
Pages (from-to)	18047-18057
Number of pages	11
Journal	Journal of Biological Chemistry
Volume	288
Issue number	25
DOIs	https://doi.org/10.1074/jbc.M113.453688
State	Published - Jun 21 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Bankston, A. N., Li, W., Zhang, H., Ku, L., Liu, G., Papa, F., Zhao, L., Bibb, J. A., Cambi, F., Tiwari-Woodruff, S. K., & Feng, Y. (2013). P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair. Journal of Biological Chemistry, 288(25), 18047-18057. https://doi.org/10.1074/jbc.M113.453688

Bankston, AN, Li, W, Zhang, H, Ku, L, Liu, G, Papa, F, Zhao, L, Bibb, JA, Cambi, F, Tiwari-Woodruff, SK & Feng, Y 2013, 'P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair', Journal of Biological Chemistry, vol. 288, no. 25, pp. 18047-18057. https://doi.org/10.1074/jbc.M113.453688

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title = "P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair",

abstract = "Background: Cyclin-dependent kinase 5 (Cdk5) is crucial for brain development. Results: In contrast to neurons that utilize p35 as the primary Cdk5 activator, oligodendroglia employ p39-dependent Cdk5 activation to advance differentiation and myelin repair. Conclusion: p39 is the primary Cdk5 activator in oligodendroglia, essential for oligodendroglia development. Significance: Our study revealed distinct mechanisms controlling Cdk5 activity in neurons and oligodendroglia.",

author = "Bankston, \{Andrew N.\} and Wenqi Li and Hui Zhang and Li Ku and Guanglu Liu and Filomena Papa and Lixia Zhao and Bibb, \{James A.\} and Franca Cambi and Tiwari-Woodruff, \{Seema K.\} and Yue Feng",

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doi = "10.1074/jbc.M113.453688",

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T1 - P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair

AU - Bankston, Andrew N.

AU - Li, Wenqi

AU - Zhang, Hui

AU - Ku, Li

AU - Liu, Guanglu

AU - Papa, Filomena

AU - Zhao, Lixia

AU - Bibb, James A.

AU - Cambi, Franca

AU - Tiwari-Woodruff, Seema K.

AU - Feng, Yue

PY - 2013/6/21

Y1 - 2013/6/21

N2 - Background: Cyclin-dependent kinase 5 (Cdk5) is crucial for brain development. Results: In contrast to neurons that utilize p35 as the primary Cdk5 activator, oligodendroglia employ p39-dependent Cdk5 activation to advance differentiation and myelin repair. Conclusion: p39 is the primary Cdk5 activator in oligodendroglia, essential for oligodendroglia development. Significance: Our study revealed distinct mechanisms controlling Cdk5 activity in neurons and oligodendroglia.

AB - Background: Cyclin-dependent kinase 5 (Cdk5) is crucial for brain development. Results: In contrast to neurons that utilize p35 as the primary Cdk5 activator, oligodendroglia employ p39-dependent Cdk5 activation to advance differentiation and myelin repair. Conclusion: p39 is the primary Cdk5 activator in oligodendroglia, essential for oligodendroglia development. Significance: Our study revealed distinct mechanisms controlling Cdk5 activity in neurons and oligodendroglia.

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SN - 0021-9258

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SP - 18047

EP - 18057

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 25

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P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair

Abstract

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