Abstract
Human pancreas and islet transplantation remains an attractive treatment option for some patients with severe type 1 diabetes (T1D). Pancreas preservation remains a critically important part of the success and cost-effectiveness of pancreas and especially islet transplantation. During preservation, the pancreas is susceptible to ischemia that has been shown to reduce the quality and function of the pancreas and likely predisposes islets to further damage during the islet isolation process when islet transplantation is pursued. It is widely accepted that improving the oxygenation during preservation improves pancreas and islet quality, which may be able to expand the donor pool, extend the preservation time, improve islet yield and quality, and ultimately reduce the number of donors needed per patient. This chapter discusses the challenges in pancreas preservation especially as they relate to the unique susceptibility of islets to ischemia and then concludes with a discussion on current clinical and research methodologies used for pancreas preservation in pancreas and islet transplantation with a focus on how they address the issue of oxygenation during preservation. Through discussion of these methodologies, we underscore the critical need for improved oxygen delivery to human pancreata during preservation.
Original language | English (US) |
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Title of host publication | Pancreas and Beta Cell Replacement |
Publisher | Elsevier |
Pages | 113-124 |
Number of pages | 12 |
ISBN (Electronic) | 9780128240113 |
ISBN (Print) | 9780128240120 |
DOIs | |
State | Published - Jan 1 2022 |
Keywords
- Ischemia
- Islets
- Oxygenation
- Pancreas preservation
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology