Oxygen in human health from life to death - An approach to teaching redox biology and signaling to graduate and medical students

Margaret M. Briehl

doi:10.1016/j.redox.2015.04.002

Oxygen in human health from life to death - An approach to teaching redox biology and signaling to graduate and medical students

Margaret M. Briehl

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

In the absence of oxygen human life is measured in minutes. In the presence of oxygen, normal metabolism generates reactive species (ROS) that have the potential to cause cell injury contributing to human aging and disease. Between these extremes, organisms have developed means for sensing oxygen and ROS and regulating their cellular processes in response. Redox signaling contributes to the control of cell proliferation and death. Aberrant redox signaling underlies many human diseases. The attributes acquired by altered redox homeostasis in cancer cells illustrate this particularly well. This teaching review and the accompanying illustrations provide an introduction to redox biology and signaling aimed at instructors of graduate and medical students.

Original language	English (US)
Pages (from-to)	124-139
Number of pages	16
Journal	Redox Biology
Volume	5
DOIs	https://doi.org/10.1016/j.redox.2015.04.002
State	Published - Aug 1 2015

Keywords

Apoptosis
Cancer
Hydrogen peroxide
Mitochondria
Proliferation
Superoxide

ASJC Scopus subject areas

Organic Chemistry
Clinical Biochemistry

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10.1016/j.redox.2015.04.002

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title = "Oxygen in human health from life to death - An approach to teaching redox biology and signaling to graduate and medical students",

abstract = "In the absence of oxygen human life is measured in minutes. In the presence of oxygen, normal metabolism generates reactive species (ROS) that have the potential to cause cell injury contributing to human aging and disease. Between these extremes, organisms have developed means for sensing oxygen and ROS and regulating their cellular processes in response. Redox signaling contributes to the control of cell proliferation and death. Aberrant redox signaling underlies many human diseases. The attributes acquired by altered redox homeostasis in cancer cells illustrate this particularly well. This teaching review and the accompanying illustrations provide an introduction to redox biology and signaling aimed at instructors of graduate and medical students.",

keywords = "Apoptosis, Cancer, Hydrogen peroxide, Mitochondria, Proliferation, Superoxide",

author = "Briehl, {Margaret M.}",

note = "Funding Information: This work was supported by NIH R01CA71768 and U54CA143924 . Publisher Copyright: {\textcopyright} 2015 The Authors.",

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AU - Briehl, Margaret M.

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N2 - In the absence of oxygen human life is measured in minutes. In the presence of oxygen, normal metabolism generates reactive species (ROS) that have the potential to cause cell injury contributing to human aging and disease. Between these extremes, organisms have developed means for sensing oxygen and ROS and regulating their cellular processes in response. Redox signaling contributes to the control of cell proliferation and death. Aberrant redox signaling underlies many human diseases. The attributes acquired by altered redox homeostasis in cancer cells illustrate this particularly well. This teaching review and the accompanying illustrations provide an introduction to redox biology and signaling aimed at instructors of graduate and medical students.

AB - In the absence of oxygen human life is measured in minutes. In the presence of oxygen, normal metabolism generates reactive species (ROS) that have the potential to cause cell injury contributing to human aging and disease. Between these extremes, organisms have developed means for sensing oxygen and ROS and regulating their cellular processes in response. Redox signaling contributes to the control of cell proliferation and death. Aberrant redox signaling underlies many human diseases. The attributes acquired by altered redox homeostasis in cancer cells illustrate this particularly well. This teaching review and the accompanying illustrations provide an introduction to redox biology and signaling aimed at instructors of graduate and medical students.

KW - Apoptosis

KW - Cancer

KW - Hydrogen peroxide

KW - Mitochondria

KW - Proliferation

KW - Superoxide

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DO - 10.1016/j.redox.2015.04.002

M3 - Review article

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AN - SCOPUS:84928232797

SN - 2213-2317

VL - 5

SP - 124

EP - 139

JO - Redox Biology

JF - Redox Biology

ER -

Oxygen in human health from life to death - An approach to teaching redox biology and signaling to graduate and medical students

Abstract

Keywords

ASJC Scopus subject areas

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