Oxidative Stress in Cancer: Therapeutic Implications of Small-Molecule Kinase Inhibitors

Shailender S. Chauhan, Neha Singh, Noel A. Warfel, Sathish Kumar Reddy Padi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer-targeted therapeutics have heavily relied on developing small-molecule kinase inhibitors as anticancer agents in the last two decades. The main reason for such attention lies in the fact that kinase dysregulation is the most common feature noticeable across a wide spectrum of cancers. Numerous investigations have produced increasing evidence projecting kinases as promising drug targets. The US Food and Drug Administration has approved 53 small-molecule kinase inhibitors as anticancer agents until recently. Currently, many such inhibitors are in clinical trials for cancer and other pathologies. As these novel inhibitors are being developed, relentless efforts are devoted to understand their mechanisms of action. Accumulating evidence has revealed that most kinase inhibitors augment free radical production which further activates various pathways to induce cell death. However, this book chapter discusses small-molecule kinase inhibitors exhibiting reactive oxygen species (ROS)-dependent mechanisms of cancer cell death.

Original languageEnglish (US)
Title of host publicationHandbook of Oxidative Stress in Cancer
Subtitle of host publicationTherapeutic Aspects: Volume 1
PublisherSpringer Singapore
Pages3809-3825
Number of pages17
Volume1
ISBN (Electronic)9789811654220
ISBN (Print)9789811654213
DOIs
StatePublished - Jan 1 2022
Externally publishedYes

Keywords

  • Apoptosis
  • Cancer
  • Oxidative stress
  • Reactive oxygen species
  • Small-molecule kinase inhibitors

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry, Genetics and Molecular Biology

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