TY - JOUR
T1 - Oxidative stress and graft coronary artery disease
T2 - Early factors contributing to late outcomes
AU - Miniati, Douglas N.
AU - Robbins, Robert C.
N1 - Funding Information:
From the Department of Cardiothoracic Surgeo,, Stanford University School of Medicine, Stanford, CA. Supported by a Research FellowshipA wardf rom t& Intenlational Society for Heart and Lung Transplantation (D.N.M.) and a Grant-in-Aidf rom the American Heart Association (R.C.R.). Address reprint requests to Robert C. Robbins, MD, Deportment of Cardiothoracic Surgeo,, Stanford University School of Medicine, 300 Pasteur Dr, Falk CardiovascularR esearch Building, Stanford, CA 94305. Copyright © 2001 by W.B. Saunders Company 0955-470X/01/1502-0002535.00/0 dm-'lO.lO53/trre.2001.21106
PY - 2001
Y1 - 2001
N2 - Graft coronary artery disease continues to obstruct the long-term success of heart transplantation. Although antigen-dependent factors play a central role, more recent data indicate the importance of antigen-independent events in this disease process. In particular, the obligatory oxidative stress that cardiac allografts incur with ischemia and reperfusion appears to be associated with later graft function and the development of vasculopathy. This review provides evidence for this link, highlights some of the molecular events in this process, and points toward therapies that may benefit heart transplant recipients in the future.
AB - Graft coronary artery disease continues to obstruct the long-term success of heart transplantation. Although antigen-dependent factors play a central role, more recent data indicate the importance of antigen-independent events in this disease process. In particular, the obligatory oxidative stress that cardiac allografts incur with ischemia and reperfusion appears to be associated with later graft function and the development of vasculopathy. This review provides evidence for this link, highlights some of the molecular events in this process, and points toward therapies that may benefit heart transplant recipients in the future.
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U2 - 10.1016/S0955-470X(05)80005-9
DO - 10.1016/S0955-470X(05)80005-9
M3 - Article
AN - SCOPUS:33750650404
SN - 0955-470X
VL - 15
SP - 102
EP - 108
JO - Transplantation Reviews
JF - Transplantation Reviews
IS - 2
ER -