Overview of the pharmacogenetics of asthma treatment

S. T. Weiss, A. A. Litonjua, C. Lange, R. Lazarus, S. B. Liggett, E. R. Bleecker, K. G. Tantisira

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations

Abstract

Asthma affects approximately 300 million individuals worldwide. Medications comprise a substantial portion of asthma expenditures. Despite the availability of three primary therapeutic classes of medications, there are a significant number of nonresponders to therapy. Available data, as well as previous pharmacogenetic studies, suggest that genetics may contribute as much as 60-80% to the interindividual variability in treatment response. In this methodologic review, after providing a broad overview of the asthma pharmacogenetics literature to date, we describe the application of a novel family-based screening algorithm to the analysis of pharmacogenetic data and highlight our approach to identifying and verifying loci influencing asthma treatment response. This approach seeks to address issues related to multiple comparisons, statistical power, population stratification, and failure to replicate from which previous population-based or case-control pharmacogenetic association studies may suffer. Identification of such replicable loci is the next step towards the goal of 'individualized therapy' for asthma.

Original languageEnglish (US)
Pages (from-to)311-326
Number of pages16
JournalPharmacogenomics Journal
Volume6
Issue number5
DOIs
StatePublished - Sep 2006
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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