Overriding Drug-Drug Interaction Alerts in Clinical Decision Support Systems: A Scoping Review

Lorenzo Villa Zapata, Vignesh Subbian, Richard D. Boyce, Philip D. Hansten, John R. Horn, Sheila M. Gephart, Andrew Romero, Daniel C Malone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ineffective computerized alerts for potential Drug-Drug Interactions (DDI) is a longstanding informatics issue. Prescribing clinicians often ignore or override such alerts due to lack of context and clinical relevance, among various other reasons. In this study, we reveiwed published data on the rate of DDI alert overrides and medications involved in the overrides. We identified 34 eligible studies from sites across Asia, Europe, the United States, and the United Kingdom. The override rate of DDI alerts ranged from 55% to 98%, with more than half of the studies reporting the most common drug pairs or medications involved in acceptance or overriding of alerts. The high prevalance of alert overrides highlights the need for decision support systems that take user, drug, and institutional factors into consideration, as well as actionable metrics to better characterize harm associated with overrides.

Original languageEnglish (US)
Title of host publicationMEDINFO 2021
Subtitle of host publicationOne World, One Health - Global Partnership for Digital Innovation - Proceedings of the 18th World Congress on Medical and Health Informatics
EditorsPaula Otero, Philip Scott, Susan Z. Martin, Elaine Huesing
PublisherIOS Press BV
Pages380-384
Number of pages5
ISBN (Electronic)9781643682648
DOIs
StatePublished - Jun 6 2022
Event18th World Congress on Medical and Health Informatics: One World, One Health - Global Partnership for Digital Innovation, MEDINFO 2021 - Virtual, Online
Duration: Oct 2 2021Oct 4 2021

Publication series

NameStudies in Health Technology and Informatics
Volume290
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365

Conference

Conference18th World Congress on Medical and Health Informatics: One World, One Health - Global Partnership for Digital Innovation, MEDINFO 2021
CityVirtual, Online
Period10/2/2110/4/21

Keywords

  • Drug interactions
  • Medical Order Entry Systems
  • Review

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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