Overnutrition and the cardiorenal syndrome: Use of a rodent model to examine mechanisms

Adam Whaley-Connell, Lakshmi Pulakat, Vincent G. Demarco, Melvin R. Hayden, Javad Habibi, Erik J. Henriksen, James R. Sowers

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, including the heart and the kidney. Furthermore, overnutrition is one of the most important modifiable and preventable causes of morbidity and mortality associated with cardiovascular and kidney diseases. Insulin resistance and compensatory hyperinsulinemia as well as associated mechanisms, including enhanced renin-angiotensin-aldosterone system activity, inflammation, and oxidative stress, have been implicated in obesity-related cardiorenal injury. In this review, the effect of overnutrition on heart and kidney disease is assessed in a rodent model of overnutrition and obesity, the Zucker obese rat.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalCardioRenal Medicine
Issue number1
StatePublished - Jan 2011
Externally publishedYes


  • Cardiorenal syndrome
  • Heart/kidney disease
  • Obesity
  • Overnutrition
  • Zucker rat model

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Urology


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