Overnutrition and the cardiorenal syndrome: Use of a rodent model to examine mechanisms

Adam Whaley-Connell; Lakshmi Pulakat; Vincent G. Demarco; Melvin R. Hayden; Javad Habibi; Erik J. Henriksen; James R. Sowers

doi:10.1159/000322827

Overnutrition and the cardiorenal syndrome: Use of a rodent model to examine mechanisms

Adam Whaley-Connell, Lakshmi Pulakat, Vincent G. Demarco, Melvin R. Hayden, Javad Habibi, Erik J. Henriksen, James R. Sowers

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, including the heart and the kidney. Furthermore, overnutrition is one of the most important modifiable and preventable causes of morbidity and mortality associated with cardiovascular and kidney diseases. Insulin resistance and compensatory hyperinsulinemia as well as associated mechanisms, including enhanced renin-angiotensin-aldosterone system activity, inflammation, and oxidative stress, have been implicated in obesity-related cardiorenal injury. In this review, the effect of overnutrition on heart and kidney disease is assessed in a rodent model of overnutrition and obesity, the Zucker obese rat.

Original language	English (US)
Pages (from-to)	23-30
Number of pages	8
Journal	CardioRenal Medicine
Volume	1
Issue number	1
DOIs	https://doi.org/10.1159/000322827
State	Published - Jan 2011
Externally published	Yes

Keywords

Cardiorenal syndrome
Heart/kidney disease
Obesity
Overnutrition
Zucker rat model

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Urology

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10.1159/000322827

Cite this

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abstract = "Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, including the heart and the kidney. Furthermore, overnutrition is one of the most important modifiable and preventable causes of morbidity and mortality associated with cardiovascular and kidney diseases. Insulin resistance and compensatory hyperinsulinemia as well as associated mechanisms, including enhanced renin-angiotensin-aldosterone system activity, inflammation, and oxidative stress, have been implicated in obesity-related cardiorenal injury. In this review, the effect of overnutrition on heart and kidney disease is assessed in a rodent model of overnutrition and obesity, the Zucker obese rat.",

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AU - Whaley-Connell, Adam

AU - Pulakat, Lakshmi

AU - Demarco, Vincent G.

AU - Hayden, Melvin R.

AU - Habibi, Javad

AU - Henriksen, Erik J.

AU - Sowers, James R.

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N2 - Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, including the heart and the kidney. Furthermore, overnutrition is one of the most important modifiable and preventable causes of morbidity and mortality associated with cardiovascular and kidney diseases. Insulin resistance and compensatory hyperinsulinemia as well as associated mechanisms, including enhanced renin-angiotensin-aldosterone system activity, inflammation, and oxidative stress, have been implicated in obesity-related cardiorenal injury. In this review, the effect of overnutrition on heart and kidney disease is assessed in a rodent model of overnutrition and obesity, the Zucker obese rat.

AB - Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, including the heart and the kidney. Furthermore, overnutrition is one of the most important modifiable and preventable causes of morbidity and mortality associated with cardiovascular and kidney diseases. Insulin resistance and compensatory hyperinsulinemia as well as associated mechanisms, including enhanced renin-angiotensin-aldosterone system activity, inflammation, and oxidative stress, have been implicated in obesity-related cardiorenal injury. In this review, the effect of overnutrition on heart and kidney disease is assessed in a rodent model of overnutrition and obesity, the Zucker obese rat.

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Overnutrition and the cardiorenal syndrome: Use of a rodent model to examine mechanisms

Abstract

Keywords

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