Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59

William C. Hahn, Elisabeth Menu, Alfred L.M. Bothwell, Peter J. Sims, Barbara E. Bierer

Research output: Contribution to journalArticlepeer-review

154 Scopus citations

Abstract

The interaction of the T cell glycoprotein CD2 with one ligand, CD58, contributes to T cell function. We have identified CD59, a glycoprotein with complement-inhibitory function, as a second physiological ligand for CD2. Antibodies to CD59 inhibit CD2-dependent T cell activation in murine T cell hybridomas expressing human CD2. In an in vitro binding assay with purified CD58 and CD59, CD2+ cells bind not only immobilized CD58 but also CD59. With two complementary approaches, it was demonstrated that the binding sites on CD2 for CD58 and CD59 are overlapping but nonidentical. These observations suggest that direct interactions between CD2 and both CD58 and CD59 contribute to T cell activation and adhesion.

Original languageEnglish (US)
Pages (from-to)1805-1807
Number of pages3
JournalScience
Volume256
Issue number5065
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • General

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