Overexpression of SOCS3 is associated with decreased survival in a cohort of patients with de novo follicular lymphoma

Ravitharan Krishnadasan; Carlo Bifulco; Julie Kim; Sofya Rodov; Arthur W. Zieske; Gary J. Vanasse

doi:10.1111/j.1365-2141.2006.06248.x

Overexpression of SOCS3 is associated with decreased survival in a cohort of patients with de novo follicular lymphoma

Ravitharan Krishnadasan, Carlo Bifulco, Julie Kim, Sofya Rodov, Arthur W. Zieske, Gary J. Vanasse

Cancer Center

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17 Scopus citations

Abstract

The prognostic significance of SOCS3 protein expression was determined in de novo follicular lymphomas (FL) with t(14;18) and bcl-2 overexpression. Presentation lymph nodes from 82 FL patients for whom clinical information was available were immunohistochemically segregated into SOCS3-positive (n = 42) or -negative (n = 40) cohorts, and overall survival (OS) was analysed. SOCS3-positive FL patients had a median OS of 10 years compared with 22 years in SOCS3-negative patients (P = 0.001, log rank test). After adjusting for Follicular Lymphoma International Prognostic Index subgroups, SOCS3 overexpression remained an independent predictor of decreased OS (P < 0.001). These findings suggest that overexpression of SOCS3 may be an independent poor prognostic variable in patients with de novo FL.

Original language	English (US)
Pages (from-to)	72-75
Number of pages	4
Journal	British Journal of Haematology
Volume	135
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2141.2006.06248.x
State	Published - Oct 2006

Keywords

Apoptosis
Cytokine
Follicular lymphoma
Prognostic factor
Survival

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2006.06248.x

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title = "Overexpression of SOCS3 is associated with decreased survival in a cohort of patients with de novo follicular lymphoma",

abstract = "The prognostic significance of SOCS3 protein expression was determined in de novo follicular lymphomas (FL) with t(14;18) and bcl-2 overexpression. Presentation lymph nodes from 82 FL patients for whom clinical information was available were immunohistochemically segregated into SOCS3-positive (n = 42) or -negative (n = 40) cohorts, and overall survival (OS) was analysed. SOCS3-positive FL patients had a median OS of 10 years compared with 22 years in SOCS3-negative patients (P = 0.001, log rank test). After adjusting for Follicular Lymphoma International Prognostic Index subgroups, SOCS3 overexpression remained an independent predictor of decreased OS (P < 0.001). These findings suggest that overexpression of SOCS3 may be an independent poor prognostic variable in patients with de novo FL.",

keywords = "Apoptosis, Cytokine, Follicular lymphoma, Prognostic factor, Survival",

author = "Ravitharan Krishnadasan and Carlo Bifulco and Julie Kim and Sofya Rodov and Zieske, {Arthur W.} and Vanasse, {Gary J.}",

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T1 - Overexpression of SOCS3 is associated with decreased survival in a cohort of patients with de novo follicular lymphoma

AU - Krishnadasan, Ravitharan

AU - Bifulco, Carlo

AU - Kim, Julie

AU - Rodov, Sofya

AU - Zieske, Arthur W.

AU - Vanasse, Gary J.

PY - 2006/10

Y1 - 2006/10

N2 - The prognostic significance of SOCS3 protein expression was determined in de novo follicular lymphomas (FL) with t(14;18) and bcl-2 overexpression. Presentation lymph nodes from 82 FL patients for whom clinical information was available were immunohistochemically segregated into SOCS3-positive (n = 42) or -negative (n = 40) cohorts, and overall survival (OS) was analysed. SOCS3-positive FL patients had a median OS of 10 years compared with 22 years in SOCS3-negative patients (P = 0.001, log rank test). After adjusting for Follicular Lymphoma International Prognostic Index subgroups, SOCS3 overexpression remained an independent predictor of decreased OS (P < 0.001). These findings suggest that overexpression of SOCS3 may be an independent poor prognostic variable in patients with de novo FL.

AB - The prognostic significance of SOCS3 protein expression was determined in de novo follicular lymphomas (FL) with t(14;18) and bcl-2 overexpression. Presentation lymph nodes from 82 FL patients for whom clinical information was available were immunohistochemically segregated into SOCS3-positive (n = 42) or -negative (n = 40) cohorts, and overall survival (OS) was analysed. SOCS3-positive FL patients had a median OS of 10 years compared with 22 years in SOCS3-negative patients (P = 0.001, log rank test). After adjusting for Follicular Lymphoma International Prognostic Index subgroups, SOCS3 overexpression remained an independent predictor of decreased OS (P < 0.001). These findings suggest that overexpression of SOCS3 may be an independent poor prognostic variable in patients with de novo FL.

KW - Apoptosis

KW - Cytokine

KW - Follicular lymphoma

KW - Prognostic factor

KW - Survival

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Overexpression of SOCS3 is associated with decreased survival in a cohort of patients with de novo follicular lymphoma

Abstract

Keywords

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