Abstract
The prognostic significance of SOCS3 protein expression was determined in de novo follicular lymphomas (FL) with t(14;18) and bcl-2 overexpression. Presentation lymph nodes from 82 FL patients for whom clinical information was available were immunohistochemically segregated into SOCS3-positive (n = 42) or -negative (n = 40) cohorts, and overall survival (OS) was analysed. SOCS3-positive FL patients had a median OS of 10 years compared with 22 years in SOCS3-negative patients (P = 0.001, log rank test). After adjusting for Follicular Lymphoma International Prognostic Index subgroups, SOCS3 overexpression remained an independent predictor of decreased OS (P < 0.001). These findings suggest that overexpression of SOCS3 may be an independent poor prognostic variable in patients with de novo FL.
Original language | English (US) |
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Pages (from-to) | 72-75 |
Number of pages | 4 |
Journal | British Journal of Haematology |
Volume | 135 |
Issue number | 1 |
DOIs | |
State | Published - Oct 2006 |
Keywords
- Apoptosis
- Cytokine
- Follicular lymphoma
- Prognostic factor
- Survival
ASJC Scopus subject areas
- Hematology