@article{b97f072078d6484ea3280a9833349b5d,
title = "Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer",
abstract = "We previously showed that the expressing level of FSH receptor (FSHR) increased from ovarian epithelial inclusions (OEIs) to benign ovarian epithelial tumors (OETs) and to borderline OETs, whereas FSHR levels decreased with an increase in carcinoma grade. The aim of this study was to investigate the role of FSHR in OET development. MCV152 cells with FSHR overexpression showed an increased cellular proliferation and invasive capacity, which was associated with reduced levels of prohibitin and RII-β expression and increased levels of HER-2/neu, c-Myc, and EGFR expression. Overexpression of FSHR may be associated with an elevated level of OET cell proliferation via an enhanced activity of potential oncogenic pathways. Therefore, the findings in this study suggest that overexpression of FSHR may play a role in OET development.",
keywords = "FSHR, Gonadotropin, Ovarian cancer",
author = "Zhenbo Zhang and Lin Jia and Youji Feng and Wenxin Zheng",
note = "Funding Information: Mr. Zhenbo Zhang is a PhD candidate in Fudan University and the project was partially supported by Hospital of Obstetrics and Gynecology and Department of Pathology Core Laboratory, Fudan University and partially supported by P30 CA23074 and University of Arizona Department of Pathology start up fund to Dr. Wenxin Zheng. We are thankful to Dr. T. Minegishi (Gumma Medical School, Gumma, Japan) to provide the expression vector of human FSHR (pcDNAhFSHR). Funding Information: This work is supported by official and not be used to individual benefit. The actions are authorized. The project was partially supported by Hospital of Obstetrics and Gynecology and Department of Pathology Core Laboratory, Fudan University and partially supported by P30 CA23074 and University of Arizona Department of Pathology start up fund to Dr. Wenxin Zheng. We declare that we have no conflict of interest. ",
year = "2009",
month = jun,
day = "8",
doi = "10.1016/j.canlet.2008.12.024",
language = "English (US)",
volume = "278",
pages = "56--64",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",
}