Over-inhibition: a model for developmental intellectual disability

Fabian Fernandez, Craig C. Garner

Research output: Contribution to journalArticlepeer-review

56 Scopus citations

Abstract

Developmental intellectual disability (DID) is a daunting societal problem. Although tremendous progress has been made in defining the genetic causes of DID, therapeutic strategies remain limited. In particular, there is a marked absence of a unified approach to treating cognitive impairments associated with DID. Here, we suggest that the brain in many DID-related disorders is subject to a basic imbalance in neuronal activity, with an increased contribution of inhibition to neural circuits. This over-inhibition, in turn, is predicted to lead to deficits in synaptic plasticity and learning and memory. We further discuss possibilities for pharmacological intervention in DID, focusing on the concept of drug-induced 'therapeutic neuroadaptation' as a means of stably enhancing constitutive circuit excitability and cognition over time.

Original languageEnglish (US)
Pages (from-to)497-503
Number of pages7
JournalTrends in Neurosciences
Volume30
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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