TY - JOUR
T1 - Outsmarting the host
T2 - Bacteria modulating the immune response
AU - Woolard, Matthew D.
AU - Frelinger, Jeffrey A.
PY - 2008/7
Y1 - 2008/7
N2 - Pathogenic bacteria and their hosts have had a two-way conversation for millions of years. This interaction has led to many measure/counter-measure responses by the host and bacteria. The host immune response has developed many mechanisms to neutralize and remove pathogen bacteria. In turn pathogenic bacteria have developed mechanisms to alter and evade the host immune response. We will review some of the mechanisms utilized by bacteria to accomplish this goal. We will also examine the current state of understanding of Francisella tularensis mediated immune evasion.
AB - Pathogenic bacteria and their hosts have had a two-way conversation for millions of years. This interaction has led to many measure/counter-measure responses by the host and bacteria. The host immune response has developed many mechanisms to neutralize and remove pathogen bacteria. In turn pathogenic bacteria have developed mechanisms to alter and evade the host immune response. We will review some of the mechanisms utilized by bacteria to accomplish this goal. We will also examine the current state of understanding of Francisella tularensis mediated immune evasion.
KW - Bacterial pathogenesis
KW - Francisella
KW - Immune evasion
KW - Intracellular bacteria
UR - http://www.scopus.com/inward/record.url?scp=62549143934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62549143934&partnerID=8YFLogxK
U2 - 10.1007/s12026-008-8021-5
DO - 10.1007/s12026-008-8021-5
M3 - Review article
C2 - 18592144
AN - SCOPUS:62549143934
SN - 0257-277X
VL - 41
SP - 188
EP - 202
JO - Immunologic Research
JF - Immunologic Research
IS - 3 SPEC. ISS.
ER -