Outsmarting the host: Bacteria modulating the immune response

Matthew D. Woolard, Jeffrey A. Frelinger

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Pathogenic bacteria and their hosts have had a two-way conversation for millions of years. This interaction has led to many measure/counter-measure responses by the host and bacteria. The host immune response has developed many mechanisms to neutralize and remove pathogen bacteria. In turn pathogenic bacteria have developed mechanisms to alter and evade the host immune response. We will review some of the mechanisms utilized by bacteria to accomplish this goal. We will also examine the current state of understanding of Francisella tularensis mediated immune evasion.

Original languageEnglish (US)
Pages (from-to)188-202
Number of pages15
JournalImmunologic Research
Issue number3 SPEC. ISS.
StatePublished - Jul 2008


  • Bacterial pathogenesis
  • Francisella
  • Immune evasion
  • Intracellular bacteria

ASJC Scopus subject areas

  • Immunology


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