Outcomes after laparoscopic Nissen fundoplication are not influenced by the pattern of reflux

A. T. Meneghetti, P. Tedesco, C. Galvani, M. V. Gorodner, Marco G. Patti

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The purpose of this study was to compare the outcomes of patients with different types of gastroesophageal reflux disease (upright, supine, or bipositional) after laparoscopic Nissen fundoplication and determine if patients with upright reflux have worse outcomes. Two hundred and twenty-five patients with reflux confirmed by 24-h pH monitoring were divided into three groups based on the type of reflux present. Patients were questioned pre- and post-fundoplication regarding the presence and duration of symptoms (heartburn, regurgitation, dysphagia, cough and chest pain). Symptoms were scored using a 5-point scale, ranging from 0 (no symptom) to 4 (disabling symptom). Esophageal manometry and pH results were also compared. There was no statistically significant difference in lower esophageal sphincter length, pressure or function between the three groups. There was no significant difference in any of the postoperative symptom categories between the three groups. The type of reflux identified preoperatively does not have an adverse effect on postoperative outcomes after Nissen fundoplication and should not discourage physicians from offering antireflux surgery to patients with upright reflux.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalDiseases of the Esophagus
Issue number2
StatePublished - Apr 2008
Externally publishedYes


  • Esophageal sphincter
  • Fundoplication
  • Gastroesophageal reflux
  • Heartburn
  • Regurgitation

ASJC Scopus subject areas

  • Gastroenterology


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